Attachment 3 February 18, 1948 letter from John R. Paul, M.D., Commission on Virus to Dr. Stokes ___________________ 333 Cedar St. New Haven __, CONN. February 18, 1948 Dr. Joseph Stokes, Jr. Children's Hospital 18th and Bainbridge Streets Philadelphia 46, Pennsylvania Dear Joe: This is in reply to your hand written request for a comment from me re your letter to Dr. MacLeod dated 11 February on the subject of funds for the reimbursement for volunteers prisoners who may be sufficiently disabled as a result of their acquiring experimental hepatitis to prevent their full return to gainful occupation. This is an administrative question and if it were to be done, I presume that the amount of money to be set aside would have to be at least $50,000. The problem I presume is whether the Board would recommend that such money be held in reserve for such an emergency. As to the second question relating to studies on humans which as you say raises a point of "ethics", I agree with your principles but believe the timing is not as opportune as it should be. Namely, that at this stage in the world situation one should proceed cautiously, until standards are set up by what over body is in "authority". I am not sure just what the rules are but I understand that Dr. Ivy at the University of Illinois has been on some type of vigilance committee which has laid down certain principles about volunteers in order to protect this country from the criticisms brought up in Germany during the Nurnberg trials. The Russians in Japan have also accused U.S. scientists of experimenting on humans. During the war we more or less made up our policies on this, but I am not sure that that is possible today and if there are to be official policies, I believe, we have to know them before any official statements could be made. Yours sincerely, John R. Paul, M.D. Director JRP:fd cc: Col. Bauer Dr. MacLeod COPIED: 12/2/94 RECORD Group: # 334 Entry: #14 File: Commission on Liver Diseases on Human Volunteers for Hepatitis Studies in Feb. 1945