ATTACHMENT 1


		 THE EXPERIMENTAL USE OF RADIOACTIVE MATERIALS
		    IN HUMAN SUBJECTS AT AEC ESTABLISHMENTS

	At the request of Dr. Shields Warren, Director, Dr. 
(ILLEGIBLE) the Subcommittee on Human Application, Committee on 
Isotopes submits the following recommendation:

	1.  Radioactive materials should be used in experiment
when information obtained will have diagnostic value, (ILLEGIBLE)
will contribute to knowledge on radiation protection.

	2.  Radioactive materials may be used in normal 
(ILLEGIBLE)

	    a.  The subject has full knowledge of the act 
	        (ILLEGIBLE) the procedure.

	    b.  Animal studies have established the  (ILLEGIBLE)
localization and excretion of the radioisotope or (ILLEGIBLE).

	3.  Radioactive materials may be used in patient 
(ILLEGIBLE) conditions of such a nature that there is no
reasonable employed producing manifest injury provided:

	     a. Animal studies have established the (ILLEGIBLE)
localization and excretion of the radioisotope, or (ILLEGIBLE)

	     b. The subject is of sound mind, has full knowledge,
given his consent to the procedure.

	     c. Full description of experimental procedures of
radiation to be received by body structures and organs.

	4.   Investigations are approved (1) by medical 
(ILLEGIBLE) the installation responsible for the investigation,
(2) by Biology and Medicine, and (3) full written descriptions
of and calculated estimates of radiation to be received by
(ILLEGIBLE) be submitted.

	5.   Radioisotopes and radiation doses are to be limited:

	     1.  Tissue radiation dose at the site of greatest
	         (ILLEGIBLE) initially be greater than 0.1 per
	         day.

	     2.  The effective net half-life which a combination
		 (ILLEGIBLE) physical half-life of radioisotope
		 and/or its derivative, should be 20 days.

	     3.  Administered material limited to those (ILLEGIBLE).