ATTACHMENT 14

21 May 1945

Lt. Colonel Hymer Friedell
P.O. Box E
Oak Ridge, Tennessee

Dear Lt. Col. Friedell:

Since the Chicago Meeting, I am somewhat lost as to what our 
program should be in the future. I am still sure however, that our 
primary concern here should be, (1) to establish an accurate and 
unquestionable method of monitoring our personnel and proceed to do 
so as fast and as often as faciliting will permit, (2) to adopt a
conservative arbitrary limit for the maximum tolerance dose and remove 
all people from further contact with material when they have reached 
that limit. I favor adopting one microgram as this limit. I agree 
with you that this is probably much too low. The urgent need however, 
for a working basis and the failure of the Chicago Meeting to establish 
a limit seems to make it imperative that we adopt a conservative value 
and go ahead. I think it quite likely that further work on the part of 
other groups will eventually establish a legal tolerance limit of at 
least one microgram. If in the meantime we have consistently retired 
personnel below the limit eventually established, the medico-legal 
aspect will have been taken care of and/still greater importance, we 
will have taken a relatively small chance of poisoning someone in case
the material proves to be more toxic than one would normally expect.

In order that we may establish an accurate, unquestionable method of 
monitoring personnel, I feel we should arrange to do the following:

1. Repeat our human study carefully on an individual whose kidney 
function has been established as normal beyond question.

2. Inject two other individuals; one with 5 gamma of uncomplexed 
plus 4 product and the other with uncomplexed plus 6. (an ideal setup 
would be to try plus 3 also)

3. Using rats substations our recent work showing that the percent of 
an injected dose excreted per day is independent of the size of the 
dose.

4. Again using rats, establish whether or not the excretion and 
metabolism of a set amount of product is the same when administered 
by a single or by multiple injections.

5. Continue to collect 24 hour urine samples from E.C. - collecting on 
every third day as long as he is available in order to, (a) that whether
or not one is justified in extrapolating the excretion time curve and, 
(b) to give us actual samples with which to try to develop a simpler
method of assaying.

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21 May 1945

Page two - continued

In keeping with a suggestion that I made to Lt. Howland and Lt. 
Goldring, in case we do continue with human studies I would like to
have Miss Ann Perley of our group go to Oak Ridge to help you. She is 
one of the most capable and industrious workers I have ever worked with. 
She has had 14 years experience in hospital laboratory work, much of it 
in studying kidney function and metabolism. She could supervise the 
collecting of samples and do the laboratory tests of kidney function and 
the clinical chemistry. She has worked with Lt. Goldring and I am sure he 
shares my opinion of her.

These suggestions are submitted for your consideration. Please talk them 
over with Colonel Warren, Lt. Howland and Lt. Goldring and advise me of 
your opinions.

Sincerely yours,


Wright H. Langham