DISCLAIMER

The following is a staff memorandum or other working document 
prepared for the members of the Advisory Committee on Human
Radiation Experiments.  It should not be construed as representing
the final conclusions of fact or interpretation of the issues. 
All staff memoranda are subject to revision based on further 
information and analysis.  For conclusions and recommendations of
the Advisory Committee, readers are advised to consult the Final
Report to be published in 1995.


                                                          TAB I-5
                           
		DRAFT - FOR DISCUSSION PURPOSES ONLY

TO:	  Members of the Advisory Committee on Human Radiation
	  Experiment

FROM:     Advisory Committee Staff 

DATE:     February 8, 1995

RE:       Army Review of Original Contract Proposal Submitted by 
	  Dr. Saenger; National Institutes of Health Review of 
	  Cincinnati Total-Body Irradiation Study



     In response to questions raised at the January 1995 Committee 
meeting, the following is a guide to Dr. Eugene Saenger's contract 
proposal to the Army to conduct total-body irradiation research, from 
the initial application to the signed contract (the Army review 
documents are attached).  Also attached is the Apr. 18, 1969 memo 
from the Chairman of the University of Cincinnati (UC) Faculty Review 
Committee (FCR) concerning the NIH's rejection of the TBI protocol.  

Document 1:Dr. Saenger submits an application for a research contract, 
           dated September 28, 1958, to the Department of the Army, 
           Office of Surgeon General, Research and Development Command; 
           the application lists a total budget of $25, 085.00 for the 
           first year, and requests $21,775.00 for the next two 
           additional years.  The grant application requested funds for 
           6 personnel -- 2 technicians, 1 physicist, 1 clinician, 1 
           statistician, and 1 secretary -- along with equipment and 
           supplies.  

Document 2:On October 20, 1958, Arthur D. Sullivan, Lt. Col., MSC, 
           Assistant Chief, Biophysics and Astronautics Research 
           Branch, U.S. Army Medical Research and Development Command 
           sends a memo to the Chief, Radiological Service, Walter Reed 
           Army Medical Center (WRAH) requesting a review of the 
           Saenger application.  The application is reviewed by the 
           following four persons: 

                    October 22, 1958 memo from John A. Isherwood, 
                    Col., M.C., Chief, Radiological Service, WRAH to 
                    Assistant Chief, Biophysics and Astronautics 
                    Research Branch, U.S. Army Medical Research and 
                    Development Command;

                    October 24, 1958 memo from Clinton S. Maupin, 
                    Col., M.C., Special Assistant for Nuclear Energy, 
                    OTSG to Deputy

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                    Commander, U.S. Army Medical Research and 
                    Development Command;

                    November 3, 1958 memo from William W. Cox, Lt. 
                    Col., M.C., Chief Medical Research Branch to Col. 
                    Sullivan;

                    November 7, 1958 memo from James B. Hartgering, 
                    Lt. Col., M.C., Director, Division of Nuclear 
                    Medicine and Chemistry to Lt. Col. Sullivan.

Document 3:Based on the favorable recommendations of the above four 
           persons, Col. Sullivan sent a memorandum, dated November 12, 
           1958 to Col. Hullinghorst, recommending that the AMS [Army 
           Medical Service] support the contract at a cost of 
           $21,775.00.  

Document 4:On October 29, 1959 [one year later], David Lambert, 
           Captain, USN, Deputy Chief of Staff, Weapons Effects and 
           Tests, Defense Atomic Support Agency (DASA), sent a memo, 
           through the DASA Chief, DASA Chief of Staff, and DASA 
           Comptroller, to the Director of Logistics, to the attention 
           of the Chief, Contract Management Branch granting authority 
           to allot funds in the amount of  $25,085 to effectuate a 
           contract with the University of Cincinnati.

           [We do not have documentation describing what occurred 
           between November 1958 and October 1959, concerning how the 
           contract went from the Army to DASA.]

               On March 2, 1960, a contract between the University of 
          Cincinnati and the Department of Defense was signed.  The 
          contract was "issued by" DASA, but states that "payment will 
          be made by" Finance and Accounts Office, U.S. Army; the 
          contract also lists "Army" under the box indicating 
          "Department."   

Document 5:Memo from Chairman of the University of Cincinnati Faculty 
           Committee on Research to the Members of the Faculty 
           Committee on Research (FCR), April. 18, 1969, describing NIH 
           review of the FCR and rejection of grants on moral grounds. 

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