ATTACHMENT B

Navy Research Proposal form Regarding Radiation Treatment
Study

Research Proposal		Research Division

 --- 98 (Hev. 10/49)

Project Number and Title (Leave number blank for new
projects)

NM 007 086 - Clinical studies at the U.S. Naval Hospital,
St. Albans, New York.

Study Number and Title NM 007 086.08 - Radiation treatment. 
Corelation or predisposition to radiation illness to other
clinical findings in patients receiving radiation therapy;

Location of Study

Naval Hospital, St. Albans, Queens, N.Y. --- end Naval
Medical Research Institute, Bethesda, Md.

Estimated Duration: Indefinite
Operational Requirement Number: (Leave blank if
undetermined): 16402

Security Classification: Unclassified (Recommended)

Subjects to be used in study, if any (Certain studies using
human subjects require Sector Approval -  ---- obtains
clearance)

Routine Therapy Patients - To receive only those dosages
indicated for disease in question

Additional Funds, if any Requiring Bureau Allocation to
Project in Present Fiscal Year: None Required

Principal Investigator:  CDR., S.F. Williams MC USN

Consultants: F.P. Ellinger, MD, Chief Radiation Biologist,
NMBI, Bethesda, MD

ILLEGIBLE

OBJECTIVES, AND EXPERIMENTAL DESIGN (continue on following
page, if necessary)

To investigate the factors responsible for the natural
resistance of man to general and local effects of ionizing
radiation.  This study is supplementary to the
investigations carried on by the Naval Hospital, Bethesda,
and the Naval Medical Research Institute under the same
title.

Experimental Design:  The occurrence of radiation sickness
will be carefully observed in patients undergoing radiation
therapy.  Threshold dose levels of X-ray for the production
of the various symptoms and changes will be determined with
due consideration of field size of the irradiated area,
over-all exposure time, section of the body and disease for
which te patient has bee irradiated.  Because of the well-
known difficulties to ascertain symptoms of radiation
sickness in patients, a special chart for daily recording of
all pertinent data will be employed, similar to that in use
at the Bethesda Naval Hospital.  Correlation of these
clinical data with urinary ILLEGIBLE excretion is
contemplated for a later phase of this study.




FOLLOWING SPACES ON THIS PAGE TO BE COMPLETED BY RESEARCH
DIVISION

PARENT PROGRAM: NAVAL MEDICINE

BASIC FIELD: THERAPEUTICS
DATE APPROVED: 26 JUNE, 1950

BRANCH CODE: 713