B-8 NUTRITIONAL BIOCHEMISTRY LABORATORIES DEPARTMENT OF FOOD TECHNOLOGY MASSACHUSETTS INSTITUTE OF TECHNOLOGY CAMBRIDGE 39, MASSACHUSETTS March 23, 1949 Dr. Clemens E. Benda Medical Director Walter Fernald School Waverly 78, Massachusetts Dear Dr. Benda: I am enclosing an outline of the experiment on radioactive calcium metabolism which we discussed at luncheon last week. After you have studied it, I wish you would telephone me so that we may discuss it and put it in final form without delay. Possibly we could schedule another luncheon with Professor Evans for Friday of this week. Sincerely, Robert S. Harris Professor of Biochemistry of Nutrition RSH:im Enclosure B-9 NUTRITIONAL BIOCHEMISTRY LABORATORIES DEPARTMENT OF FOOD TECHNOLOGY MASSACHUSETTS INSTITUTE OF TECHNOLOGY CAMBRIDGE 39, MASSACHUSETTS April 13, 1949 Dr. Clemens E. Benda Medical Director Walter Fernald School Waverly 78, Massachusetts Dear Dr. Benda: I am enclosing two copies of the revised outline of the experiment on radioactive calcium metabolism which will be discussed at luncheon on Monday, the 18th, at the Hotel Puritan. Sincerely, Robert S. Harris Professor of Biochemistry of Nutrition RSH:im Enclosure(2) B-9/A Outline of Proposed Experiment to Determine the Absorption of Calcium by Children and the Effect of Phytates upon Calcium Absorption In this study data will be obtained on the retention of calcium by normal children and children with mental abnormalities which may affect calcium metabolism. This type of study has not been possible in the past because calcium balance studies are difficult to conduct on human subjects, are very expensive, and the results obtained are difficult to interpret. By the use of radioactive calcium, it is possible to obtain information on calcium retention promptly at little inconvenience to the subject. Since the ingested calcium has a radioactive label, an exact measurement of its excretion can be made and positive conclusions regarding its retention and excretion can be drawn from the laboratory data. A. General Outline Radioactive calcium (Ca45) will be administered to adolescent children in the following test meals: Test 1. In aqueous solution in the form of calcium chloride. Test 2. Incorporated into a serving of oatmeal (without milk). Test 3. Incorporated into a serving of hydrolyzed oatmeal (without milk). The hydrolysis will destroy the natural phytic acid content. Test 4. In aqueous solution in the form of calcium chloride, with sodium-phytate added. The amount of phytate to equal, the phytate content of the oatmeal (Test 3), These experiments will be performed on children whose intestinal tracts are normal. Test 1 will also include groups of mentally abnormal patients (cretins, mongoloids, those who suffer with achondralplasia and chondrolipodystrophy) whose calcium metabolism is believed to be abnormal. By this investigation we expect to obtain the following information: 1. The total absorption of calcium by adolescent human subjects. 2. The effect of phytate in cereals (oatmeal) upon calcium absorption. 3. The effect of soluble phytate upon calcium absorption. 4. The effect of constituents of oatmeal other than phytate upon calcium absorption. 5. The effect of certain mental disorders upon calcium absorption. B. Details of the Experimental Procedure 1. Time of Feeding. Each test feeding will be made at 7 AM in lieu of breakfast. No other food will be eaten from 7 PM of the previous evening till the noon meal on the test day. Water will be permitted except within 1 hour before and after the test feeding. -2- 3-9/A 2. Amount of Calcium. Each test meal will contain 250 mg. of calcium, either in the natural food or as added calcium chloride. All calcium supplements will be fed after solution in distilled water. 3. Amount of Radioactive Calcium Fed. The amount of Ca45 fed in each test will be the minimum which can be used and still provide significant scientific data. No subject will receive more than 2 microcuries. A subject will be used in two test periods. If possible he will be used in more than two tests. 4. Number of Subjects. The number of normal subjects required in this study will be determined by the size of dose of radioactive calcium eventually employed. If each subject can be used in only two tests, a total of at least 20 normal subjects will be necessary. There will be no limit on the number of abnormal subjects that may be studied. C. Preparation of Subjects for Experiment 1. Preliminary diet. During a preliminary period of 4 weeks each subject will receive a multi-vitamin supplement, also iron and an extra pint of milk daily. This should fill the calcium stores and raise all subject to a uniform level of calcium saturation. 2. Health examination. At the beginning and end of each experiment all subjects will undergo a complete physical examination. Laboratory tests will include a complete blood analysis and serum calcium and serum phosphorus determination. D. Preliminary Experimentation To our knowledge this type of experiment has not been attempted by others. Though we have conducted studies on experimental animals, we do not know what proportion of the radioactive calcium ingested will appear in the urine of human subjects, nor do we know how long it will be excreted in measurable amounts. Accordingly, two subjects will be put on a preliminary test, fed one microcurie of Ca45 in test meal #1, and data will be obtained ont he rate and amount of its excretion. E. Supervision of Research Program 1. The subjects will be under the immediate care and supervision of Dr. Clemens E. Benda, Medical Director of the Walter Fernald School. 2. The feeding of the subjects at the Walter Fernald School and The processing of the samples will be supervised by Dr. Robert S. Harris, Professor of Biochemistry of Nutrition, Massachusetts Institute of Technology. All technical operations will be carried out by Mr. Andrew C. Peacock of his staff. B-10 April 20, 1949 Dr. Henry A. Tadgell Superintendent Belchertown State School Belchertown, Mass Dear Dr. Tadgell: The enclosed Research Program is a joint study between the M.I.T. and the Walter E. Fernald State School. A similar study has been done a few years ago with Dr. Cooke when he was Assistant Superintendent at this school. The study does not include any danger to the life or health of the patient but it appears desirable to receive the official approval of Dr. Perkin's Research Committee of the Department of Mental Health of which you are chairman. Since there is interest that the preliminary steps be completed as quickly as possible, we would appreciate it if you would present the matter at the next meeting of the committee and provide an approval of the research study. Sincerely yours, Clemens E. Benda, M.D. Clinical Director CEB/P enc. B-11 MASSACHUSETTS INSTITUTE OF TECHNOLOGY DEPARTMENT OF PHYSICS CAMBRIDGE 39, MASS. April 26, 1949 Dr. Clemens Benda Medical Director Walter Fernald School Waverly 78, Massachusetts Dear Dr. Benda: Enclosed are: (1) four copies of AEC Form 313 "Application for Radioisotope Precourment" made in the name of Walter Fernald School, which are complete with the exception of item 2 - Department, your signature, and the date. The original and 2 carbons of this are to go forward to the AEC, the fourth copy is for your files. (2) four copies of Form 313 made in the name of M.I.T. and already signed by Robley D. Evans. Three of these should also go forward to the AEC, the fourth again being for your files. (3) a letter from Professor Evans to Dr. Paul C. Aebersold recommending your application. This should also go to AEC with items (1) and (2). In addition to the above three items, the following should be sent to the AEC: (1) a letter from the director of the Fernald School, giving the names of the Walter Fernald School Isotopes Committee and indicating one of these as chairman of this Committee. (2) a letter from the chairman of this Committee indicating approval for the Committee of your application. All five documents should be addressed as indicated on the top of Form 313 and marked Attention of Dr. Paul C. Aebersold. This will complete all of the red tape with the exception of one form called Acceptance of Terms and Conditions for Order and Receipt of By-product Materials (Radioisotopes), which will be mailed to you from the AEC subsequent to the receipt of your application. If you have any questions, please don't hesitate to call on me. Sincerely yours, Joel B. Bulkley JBB:m Enclosures 9 B-12 The Commonwealth of Massachusetts Department of Mental Health ADVISORY COMMITTEE ON PSYCHIATRIC EDUCATION AND RESEARCH May 7, 1949 Dr. Malcolm J. Farrell, Superintendent Walter E. Fernald State School Boc C Waverley 78, Massachusetts Dear Doctor: Attn: Dr. Clemens E. Benda At a regular meeting of this Committee held on April 27, 1949, the protocol submitted from the Walter E. Fernald State School entitled, 'OUTLINE OF PROPOSED EXPERIMENT TO DETERMINE THE ABSORPTION OF CALCIUM BY CHILDREN, AND THE EFFECT OF PHYTATES UPON CALCIUM ABSORPTION" was presented. After a goodly amount of discussion, it was voted to defer approval of this project, and same will be considered again at our next meeting scheduled for June 7, 1949. Dr. Benda is invited to be present at this meeting in order to discuss any question which may arise relative to the proposed experiment. A notification card will be sent to him in due season. Sincerely yours, M.D. Secretary HAT:SS B-13 May 18, 1949 Dr. Paul C. Acbersold Isotopes Branch U.S. Atomic Energy Commission P. O. Box E Oak Ridge, Tennessee Dear Dr. Acbersold: As Chairman of the Isotopes Committee, I confirm the formation of this Committee, the names of which are indicated in letter of the Director of Research. I approve of the proposed research. Sincerely yours, Malcolm J. Farrell, M.D. Superintendent MJF:may B-13/A May 18, 1949 Dr. Paul C. Aebersold Isotopes Branch U. S. Atomic Energy Commission P. O. Box E Oak Ridge, Tennessee Dear Dr. Aebersold: In complying with the requirements, I beg to inform you that an Isotopes Committee has been formed in order to supervise the proposed research at the Walter E. Fernald State School. The Committee consists of the following members: Chairman: Malcolm J. Farrell, M. D. - Superintendent, Walter E. Fernald State School; Diplomate Board of Psychiatry. Clemens E. Benda, M. D. - Director of Research and Clinical Psychiatrist; Diplomate Board of Psychiatry and Neurology. Earl MacA. Chapman, M. D. - Instructor in Medicine, Harvard Medical School; Associate in Medicine, Massachusetts General Hospital Maximilian Weinberger, M. D. - Diplomate Board of Psychiatry; Assistant Physician, Walter E. Fernald School. Elizabeth Belm,ont, M. D. - Physician, Walter E. Fernald School. Sincerely yours, Clemens E. Benda, M. D. Approved: ________________________ Malcolm J. Farrell, M. D. Superintendent CEB:may The Commonwealth of Massachusetts Department of Mental Health ADVISORY COMMITTEE ON PSYCHIATRIC EDUCATION AND RESEARCH William Malamud, M.D. Walter E. Barton, M.D. Henry A. Tadgell,M.D. Chairman Vice-Chairman Secretary Stanley Cobb, M.D. George E. Gardner, M.D. Roy G. Hoskins, M.D. John M. Murray,M.D. C. Stanley Raymond, M.D. David Rothschild,M.D. Harry C. Solomon,M.D. Douglas A. Thom, M.D. Jackson M.Thomas,M.D. June 8, 1949 Dr. Malcolm J. Farrell, Superintendent Walter E. Fernald State School Waverley, Massachusetts Attention: Dr. Clemens E. Benda Dear Dr. Farrell: At a regular meeting of this committee held on June 7, 1949, the conjoint protocol submitted from the Walter E. Fernald State School and the Massachusetts Institute of Technology entitled, "Outline of Proposed Experiment to Determine the Absorption of Calcium by Children and the Effect of Phytates upon Calcium Absorption", was again given consideration. I am pleased to inform you that the Committee unanimously approved of the project and we are glad that Dr Benda could be present to answer certain questions in the minds of the members of the Committee. Very truly yours (signed Henry A. Tadgell, M.D.) Secretary B-14 UNITED STATES ATOMIC ENERGY COMMISSION IR:SAL Oak Ridge, Tennessee September 28, 1949 Dr. Clemens E. Benda Department of Research Walter Fernald School Waverly 78, Massachusetts Subject: AUTHORIZATION NO. 3435 Dear Dr. Benda: Enclosed is Authorization No. 3435 providing for the procurement of up to three millicuries of Ca 45 of high specific activity from the Massachusetts Institute of Technology. A carbon copy of a letter to Dr. Robley D. Evans is enclosed for your information. We regret the delay which arose in connection with handling this application. It is improbable that similar situations would arise in the future and we can assure you that more prompt handling will be possible in case you file additional applications for isotopes. We look forward to serving your future needs for radioactive materials. Very truly yours, S. Allan Lough, Chief Radioisotopes Branch Isotopes Division Oak Ridge Operations Encls.: 1. Cy. ltr. fm. SAL, 9/28/49 2. Form 374, Ho. 3435 (in dup.) 3. Certificate, No. 3435 (in quad.) 4. Form 313, w/instructions B-15/A Form AEC 374 Serial No. (Mar. 1, 1948 3435 B.B. 18-R031. UNITED STATES ATOMIC ENERGY COMMISSION AUTHORIZATION FOR RADIOISOTOPE PROCUREMENT TO: Walter Fernald School Related to 3434 Department of Research Waverly 78, Massachusetts Date (Attn: Dr. Clemens E. Benda) September 28, 1949 ___________________________________________________________________ The original of this form is the only approval for procurement and must accompany your purchase order. All duplicates are for informational and record proposes only. Your application for by-product materials is approved for the materials stated below, subject to and in accordance with your application and all laws and regulations applicable hereto. ___________________________________________________________________ 1. Price List Item No. 2. Element and Isotope 3. Form H-13A Calcium 45 High Specific Activity ___________________________________________________________________4. Total Quantity Approved Three millicuries - As requested ___________________________________________________________________ 5. Use of This Material is Authorized For The Following Purpose(s): To determine the absorption of calcium by children and the effect of phytates upon calcium absorption. Only one dose to be administered to normal children. ________________________________________________________________ 6. This material is not available from Atomic Energy Commission Facilities. _______________________________________________________________ For the United States Atomic Energy Commission THIS AUTHORIZATION EXPIRES Six months after date of issue (Signed S. Allan Lough) unless extended by the By _______________________________ Commission for Chief, Isotopes Division, Oak Ridge Operations, Oak Ridge, Tennessee. ___________________________________________________________________ INSTRUCTIONS TO APPLICANT To procure the material it is necessary that you forward the items checked below to a distributor or supplier: X PURCHASE ORDER FROM YOUR INSTITUTION X THE ORIGINAL COPY OF THIS FORM (374) X THREE COPIES OF THE ENCLOSED CERTIFICATE OF COMPLIANCE WITH FEDERAL FOOD, DRUG, AND COSMETIC ACT," FORM AEC-465 Note - In ordering these materials address your purchase order to: Massachusetts Institute of Technology Cambridge 39, Massachusetts (Attn: Dr. Robley D. Evans) ___________________________________________________________________ INSTRUCTIONS TO SUPPLIER 1. Advise the Isotopes Division promptly of all shipments made under this authorization. In authorizing these materials for the uses stated in the application the Commission makes no warranty or representation that such use will not infringe any patent or patents and the authorization should not be construed as approval or acquiescence by the Commission in any infringing use of these materials. B-15/B Form AEC-313 (Rev. Mar. 1, 1945) APPLICATION FOR RADIOISOTOPE PROCUREMENT THE U.S. ATOMIC ENERGY COMMISSION, POST OFFICE BOX E., OAK RIDGE, TENNESSEE. ATTENTION: ISOTOPES DIVISION (See instructions) 1. NAME AND ADDRESS OF APPLICANT (Institution, firm, etc. See Instruction No 2) Mass. Inst. of Tech. Cambridge 29, Mass 2.DEPARTMENT Food Technology and Physics 3.NAME AND TITLE OF SCIENTIFICALLY TRAINED INDIVIDUAL WHO WILL USE OR DIRECTLY SUPERVISE USE OF MATERIAL. Robley D. Evans, Professor of Physics Robert S. Harris, Professor of Biochemistry of Nutrition ___________________________________________________________________ RADIOISOTOPE REQUESTED (See Instruction No. 3) 4. ELEMENT AND ISOTOPE 5. CHEMICAL FORM Ca 45 high spec act CaO or CaCO3 6. QUANTITY DESIRED(Number of millicuries for separated materials, number of units for irradiated units) 1 irradiation unit 7. TO BE DELIVERED AT THE RATE OF (Specify quantity per week, month,etc.) One Shipment 8.CATALOG ITEM NUMBER (If material is to be acquired from a source other than AEC, omit the catalog number. Please state name and address of the person from whom material will be obtained, if known) 13A high specific activity ___________________________________________________________________ STATEMENT OF USE (See Instruction No. 4) ___________________________________________________________________ 9.STATE PROPOSED USE OF RADIO MATERIAL AND GENERAL PLAN OF INVESTIGATION See application of Walter Fernald School. Ca 45 will be processed here for administration and samples will be measured here. 10. THE RADIOISOTOPE WILL BE USED IN HUMAN BEINGS (See Instruction No. 5) check one X Yes No 11. THE RADIOISOTOPE WILL BE USED IN ANIMALS (See Instruction No. 5) Check one Yes X No 12. (To be filed out only if prior application has been filed) HAS THERE BEEN ANY CHANGE IN AVAILABILITY OF ITEMS CALLED FOR INPART TWO OF THIS APPLICATION check one Yes XNo 13. THE ISOTOPES DIVISION MAY MAKE GENERAL STATEMENTS FOR RELEASE INTHE PUBLIC PRESS REGARDING MATERIAL USED AND THE PURPOSE FORWHICH USED Check one X Yes No ___________________________________________________________________ The applicant and any official executing this application in behalf of the applicant certify that the information stated herein is true and correct and agree that The Terms and Conditions for Order and Receipt of Byproduct Materials (radioisotopes) accepted by the applicant and filed with the Atomic Energy Commission are a part hereof. 4/26/59 (Signed Robley D. Evans) ____________________ ____________________________________ Date (Signature of applicant of certifying Official) ___________________________________________________________________ Section 35 (a) of the United States Criminal Code, 18 USC, Sec. 80 makes it a criminal offense to make a willfully false statement or representation to any department or agency of the United States as to any matter within its jurisdiction. B-15/D Form AEC-234 (May 14, 1948) ORDER BLANK NAME ____________________________________________________________ (Print or type) STREET AND NO. __________________________________________________ (Print or type) CITY AND STATE___________________________________________________ DOCUMENT NO. TITLE NUMBER OF PRICE OF TOTAL COST COPIES EACH COPY WANTED ___________________________________________________________________ UNITED STATES ATOMIC ENERGY COMMISSION DOCUMENT SALES AGENCY Penalty For Private Use To Avoid P. O. BOX 62 Payment of Postage $300 OAK RIDGE, TENN. (GPO) __________ OFFICIAL BUSINESS PERMIT NO. 1067 NAME _______________________________ STREET AND NO. _____________________ CITY _______________ STATE _________ (Print or type) B-15/E UNITED STATE ATOMIC ENERGY COMMISSION DOCUMENT SALES AGENCY P. 0. BOX 62 OAK RIDGE, TENNESSEE The following list of Atomic energy Commission Documents, issued by the Technical Information Branch, Oak Ridge, is a listing of all publications made available for sale during the month of August. Additional lists will be issued as more documents become available. Please enclose money order or check made payable to the Treasurer of the United States, and mail to Document Sales Agency, P. O. Box 62, Oak Ridge, Tennessee. STAMPS CANNOT BE ACCEPTED These documents were not written for publication. They are made available in their present form, and without review by the author, only because of the urgency is releasing information to the public. LIST NO. 14 OCTOBER 1949 BIOLOGY AND MEDICINE AECU-51 Brookhaven Conference Report. Symposium on Radioiodine. (114 p) (1948) $1.50 MDDC-954 The Metabolism of Short-Lived Air-Borne Fission Products (39 p) (1945) .20 MDDC-999 Effects of Single Doses of X-Rays on Rabbits (1944) (47 p) .20 AECD-2358 A Study of the Treatment of Plutonium and Radio- yttrium Poisoning by Zirconium Citrate (12 p) (1948) .10 AECD-2361 The Vitro Incorporation of the Methylene Carbon Atom of Glycine into Rabbit Bone Morrow Fats (2 p) (1948) .05 AECD-2428 Studies of the Unsaturation of Phospholipid Fatty Acids of the Liver, Kidney, and Blood of Uranium- Poisoned Rats (24 p) (1948) .15 AECD-2447 Development of a Tissue Radiation Fluorometer (3 p) (1949) .05 CHEMISTRY MDDC-1228 The Absorption and Fluorescence Spectra of Bivalent Europium Ion in Crystals (10 p) (1947) .10 MDDC-1295 The Vapor Pressure of Uranium Hexafluoride (7p) (1947) .10 AECD-2235 Pentavalent Manganese (5 p) (1948) .05 AECD-2265 The System Uranyl Sulfate-Water II. Temperature- Concentration Relationships above 250oC (7p) (1948) .10 AECD-2342 The Spectrochemical Determination of Hafnium- Zirconium Ratios (19 p) (1948) .10 AECD-2345 The volatilization of BeO in the Presence of H2O (3p) (1948) .05 AECD-2365 The Determination of Hydrogen (10 p) (1948) .10 AECD-2370 I. The Synthesis of Toluene-1,3,5, -C 14 and Oxalic Acid-C 14 From Pyruvic Acid-C 14, II. The Mechanisms of the Reaction (11 p) (1948) .10 AECD-2387 The Separation of Zirconium and Hafnium by Extraction with Thenoyl trifluoro acetone (5 p) (1948) .05 AECD-2400 The Synthesis of D-Glucose -1-C 14 (87 p) (1948) .30 AECD-2401 The Action of Aluminum Chloride of Chlorofluoro- carbons (3 p) (1948) .05 AECD-2429 Chemistry of Thorium in Aqueous Solutions. I. The Thorium-Iodate System Solubility and Complexes (19 p) (1948) .10 AECD-2437 A Rapid Calorimetric Method for the Determination of Micro-quantities of Thorium (13 p) (1949) .10 AECD-2440 Pragmagnetic Susceptibilities and Electronic Structures of Aqueous Cations of Elements 92 to 95 (19 p) (1949) .10 AECD-2443 Spectrophotometric Evidence for the Existence of Uranium Pentachloride as the Double Compound UCI6- UCI4 (5 p) (1949) .05 AECD-2459 Graphical Representation of the Four Series of Isotopes (Revised) (3 p) (1949) .10 AECD-2460 Chemistry of Aqueous Uranium (V) Solutions. I. Preparation and Properties. Analogy Between U(V), Np(V) and Pu(V) (32 p) (1949) .15 AECD-2478 The Spectra of the Heavy elements (20 p) (1949) .10 AECD-2523 Uranium Trifluoride - A Summary Report (7 p) (1949) .10 AECD-2546 The Vapor Pressure of Tellurium and Selenium (Final Report) (12 p) (1948) .10 AECD-2625 Current Radiochemical Research at Los Alamos. Proposed Talk to Be Given at Brookhaven National Laboratory (6 p) (1948) .05 AECD-2627 A Summary of Nuclear Chemistry Work at Argonne (e p) (1949) CHEMISTRY (cont.) B-15/E (cont.) AECD-2647 Alkaline Earth Polyuranates (6 p) (1949) $ .05 INSTRUMENTS MDDC-544 Test of Butterfly Valve with Magnetic Transmission (14 p) (1946) MDDC-1495 Progress Report Low Geometry Alpha Forticle Ionization Chambers (11 p) (1947) .10 MDDC-1531 Conversion of Air Proportional Counter Alpha Detection Instruments (Poppy) to Detect C14 Contamination and Soft Beta Radiation (4p)(1947) .05 MDDC-1639 Construction of a Hand-Contamination Counter and Radiation Monitor (8 p) (1947) .10 AECD-2410 "Poppy"- Pulse type Detector for Alphas, Betas, Gammas,and Neutrons (20p) (1948) .10 AECD-2535 Operations Manual for a Parallel Plate Alpha Counter (Scale of 64) (24 p) (1948) .15 METALLURGY AND CERAMICS MDDC-1058 High Temperature Equilibria in Metal - Metal Halide Systems (20p) (1947) .10 AECD-2237 Pure Refractory Materials (3p) (1948) .05 AECD-2464 Sintering Corbides by Means of Fugitive Binders (35 p) (1949) .20 AECD-184 A Transient Analysis of the Cathode - Coupled Feedback Loop (26 p) (1949) .15 MDDC-0935 Studies of Capture of Gamma rays (37p)(1947) .20 AECD-2250 Preliminary Results on the Cross Section of the Reaction T3 (d,n)He4 Between 1.0 Mev and 2.5 Mev Deuteron Energy (13p) (1948) .10 AECD-2304 Evidence for A p,d Reaction in carbon (3p) (1948) .05 AECD-2340 Relative Cross Sections of Nuclear Reactions Induced by High Energy Neutrons in Light Elements (8 p) (1948) .10 AECD-2368 Graphs Showing Neutron Cross section as Functions of A, Z, or N (8p) (1948) .10 AECD-2382 Alpha Particles From Fission as Recorded by Photographic Emulsions (11 p) (1948) .10 AECD-2438 On the derivation and Integration of the Pile- Kinetic equations (17 p) (1949) .10 AECD-2449 Slowing Down on Neutrons in Polychrystalline Solids (10 p) (1949) .10 AECD-2533 Inelastic Scattering of Lead for 14.5 MEV Neutrons (4 p) (1949) .05 AECD-2569 Energy Loss of Deuterons in D2O at very Low Energies (20 p) (1949) .10 AECD-2585 Half-Life of Tritium (9 p) (1949) .10 AECD-2641 Conductivity Changes in Dielectrics During 2.5 MEV X-Radiation (3 p) (1949) .05 AECD-2664 Neutron Physics (96 p) (1945) .35 SUBSCRIPTION RATES FOR NUCLEAR SCIENCE ABSTRACTS Volume 1 July 15 - December 30, 1948 (12 issues) (each 0,30, except No. 12, 0.45) 3.75 Volume II January 15 - June 30, 1949 (12 issues)Each,0.25 3.00 Volume III July 15 - December 30, 1949 (12 issues) Each,0.25 3.00 Volume IV January 15 - June 30, 1950 (12 issues) Each, 0.25 3.00 A subscription for either of the volumes includes the cumulative subject and author index. B-15/E (cont.) DEPOSIT ACCOUNTS This office will now accept orders on deposit accounts made out on regular deposit order blanks in triplicate as obtained from the Superintendent of Documents, Washington 25, D. C. All order blanks must have the deposit account number assigned by Superintendent of Documents on all copies before they can be honored by this office. However, all orders must be directed to the Document Sales Agency, P. O. Box 62, Oak Ridge, Tennessee and not to the Superintendent of Documents. New deposit accounts may be opened with Superintendent of Documents, Washington 25, D. C., the minimum amount being ($5.00) five dollars. New depositors may restrict their accounts to charges for Atomic Energy Commission documents only, or may open a general account for the purchase of any government publications. DISCOUNTS I. Quantity Discounts. 1. A quantity discount of 25% will be allowed only on orders of 100 or more copies of the same publication to be sent to one address. On orders for several different publications of which one is for 100 or more copies and the others for lesser amounts, the discount will be allowed only on the publication where 100 or more are ordered, the others are to be sold at the list price. II. Bookdealers Discounts. 1. All authorized bookdealers, recognized as such by their order on a letterhead proclaiming their business or by a statement to the effect that their purchase is for the purpose of resale, are entitled to 25% discount. 2. Authorized bookdealers will be allowed a 25% discount on orders of 100 or more publications which are to be sent to different addresses. FOREIGN POSTAGE No charge is made for postage on documents forwarded to points in the United States and possessions, or to Canada, Cuba, Mexico, Newfoundland (including Labrador) and certain Central and South American countries. To other countries the regular rate of postage is charged, and remittances must cover such postage. In computing foreign postage, add one-third of the price of the publication(s). B-16 IR:SAL UNITED STATES ATOMIC ENERGY COMMISSION Oak Ridge, Tennessee September 28, 1949 Dr. Robley D. Evans Department of Physics Massachusetts Institute of Technology Cambridge 39, Massachusetts Subject: AUTHORIZATIONS NO. 3434 AND 3435 Dear Dr. Evans: Enclosed is Authorization No. 3434 providing for procurement of three millicuries of Ca 45 in acid solution. This material will be of high specific activity and is listed as Catalog Item H-13A on page 24 of the July 1949 catalog. We note that you have applied for one irradiated unit of Ca 45 as CaCO3, Catalog Item No. 13A. One irradiated unit contains about three millicuries of Ca 45. Since you specified material of high specific activity, however, we have taken the liberty of allocating the material mentioned above. It may be that you will not desire to order as much as three millicuries of Ca 45, Catalog Item No. H-13A. If a smaller amount will be adequate for your purposes, you need only to place an order for the amount really desired. Under separate cover we have sent to Dr Benda Authorization No. 3435 providing for procurement of the processed Ca 45 from the Massachusetts Institute of Technology. At the recommendation of our Subcommittee on Human Applications, we have stipulated that only one dose of Ca 45, is to be administered to each normal child used in the study. We regret the delay in handling this application, which was caused by the circumstances described in Dr. Woodruff's letter to you, dated September 12, 1949, and by the necessity to resubmit the application to the Subcommittee because of differences of opinion expressed in the first review. B-15/C (Con't) 2 Dr. Robley D. Evans September 28, 1949 We look forward to the opportunity to serve your future needs for radioisotopes and assure you that every effort will be made to handle your applications promptly. Very truly yours, S. Allan Lough, Chief Radioisotopes Branch Isotopes Division Oak Ridge Operations Encls. 1. Form 374, No. 3434 (in dup.) 2. Certificate No. 3434 (in quad.) 3. Form 313, w/instructions cc: Dr. Clemens E. Benda B-17 October 27, 1949 S. Allan Lough, Chief Radioisotopes Branch Isotopes Division Oak Ridge Operations Oak Ridge, Tennessee Dear Mr. Lough: We confirm the authorization of the United States Atomic Energy Commission for the use of three millicuries of Ca 45 to determine the absorption of calcium by children. The authorization, Serial Number 3435, states: "Only one dose to the administrated to normal children." The interpretation of this statement by the physicist is that one dose means the physical unit of three millicuries which could, however, be given for instance in three fractions of one millicurie each time at various intervals. Will you please be good enough to confirm this interpretation or otherwise correct it. Sincerely yours, Clemens K. Benda, M. D. Clinical Director Approved: Malcolm J. Farrell, M. D. Superintendent CEB:may B-18 UNITED STATES ATOMIC ENERGY COMMISSION IR:JRM Oak Ridge, Tennessee November 3, 1949 Dr. Clemens K. Benda Walter E. Fernald State School Box C Waverley 78, Massachusetts Subject: AUTHORIZATION NO. 3435 Dear Dr. Benda: This office is pleased to reply to your letter of October 27 regarding the dosage restriction placed on Authorization No. 3435 by our Subcommittee on Human Applications. Only one dose to be administered to normal children was meant to indicate that each normal patient used in your study would receive radiocalcium one time only. There also appears to be some misinterpretation of the authorized dosage. Your letter of October 27 states "the interpretation of this statement by the physicist is that one dose means the physical unit of three millicuries which could, however, be given, for instance, in three fractions of one millicurie each time at various intervals." It should be pointed out that 3 mc is the total activity authorized for your program. The individual dosage was approved for the amount shown in the outline attached to your Application No. 3435. This was: "3. Amount of Radioactive Calcium fed. The amount of Ca 45 fed in each test will be the minimum which can be used and still provide significant scientific data. No subject will receive more than 1 microcurie. A subject will be used in two test periods. If possible he will be used in more than two tests". To summarize, you are authorized to conduct your investigation as you originally requested using the minimum amount of Ca 45 which would provide significant scientific data in each test. Mentally deficient subjects may be used in more than one test providing the total Ca 45 administered per subject does not exceed one microcurie. The Subcommittee on Human Applications further recommended that normal control subjects be used in none test only with the minimum possible Ca 45 and in no case to exceed one microcurie. B-18 (cont.) 2 Dr. Clemens E. Benda November 3, 1949 We trust these arrangements are satisfactory for the conduct of your investigation. If we can be of further assistance, feel free to call on us. Very truly yours, S. Allan Lough, Chief Radioisotopes Branch Isotopes Division Oak Ridge Operations B-19 GRAPHIC THE COMMONWEALTH OF MASSACHUSETTS DEPARTMENT OF MENTAL HEALTH Malcolm J. Farrell, M.D. Superintendent WALTER E. FERNALD STATE SCHOOL BOX C. WAVERLEY 78, MASS. November 2, 1949 The Massachusetts Institute of Technology and this institution are very much interested in the various aspects of nutrition, particularly how the a body absorbs various cereals, iron and vitamins. We are considering the selection of a group of our brighter patients, including ...... to receive a special diet rich in the above mentioned substances for a period of time. We wish to keep an accurate record of the effect of these substances, such as gains in weight and other improvements, particularly in the blood. It will be necessary to make some blood tests at stated intervals, similar to those to which our patients are already accustomed, and which will cause no discomfort or change in their physical condition other than possibly improvement. The Massachusetts Institute of Technology plans to reward patients taking part. Enclosed please find a blank which I request that you sign and return in the enclosed stamped addressed envelope, as soon as possible. The signed and witnessed blank will signify that you have no objection to your son participating in this project as outlined above. You may rest assured that I personally feel this project will be of great importance and that much valuable information concerning nutrition can be obtained which eventually will be of considerable benefit to mankind. I hope that I can count on your cooperation. Very truly yours, _____________________________ Malcolm J. Farrell, M. D., Superintendent. MJF:d Enclo. B-19(cont.) TO THE SUPERINTENDENT OF THE WALTER E. FERNALD STATE SCHOOL: This is to state that I give my permission for the participation of ____________________ in the project mentioned in your letter of Witnessed by: _______________________________ Signature ___________________ _______________________________ Date: _____________ Relationship TO THE SUPERINTENDENT OF THE WALTER E. RERNALD STATE SCHOOL: This is to state that I give my permission for the participation of ______________________ in the project mentioned in your letter of Witnessed by: _________________________________ Signature ______________________ __________________________________ Date: ________________ Relationship TO THE SUPERINTENDENT OF THE WALTER E. RERNALD STATE SCHOOL: This is to state that I give my permission for the participation of ______________________ in the project mentioned in your letter of Witnessed by: _________________________________ Signature ______________________ __________________________________ Date: ________________ Relationship B-20 NUTRITIONAL BIOCHEMISTRY LABORATORIES DEPARTMENT OF FOOD TECHNOLOGY MASSACHUSETTS INTITITUTE OF TECHNOLOGY CAMBRIDGE 39, MASSACHUSETTS March 10, 1950 Robert S. Harris, PH.D., In Charge Hazel E. Munsell, PH.D. Henry Sherman, PH.D. Louis O. Williams, PH.D. Louise P. Guild, B.S. Rita E. Brent, B.S. Lucille T. Kelley, B.S. Mera R. Jetton, M.A. Alina S. Szciesniak, A.B. Ann McNally, A.B. Charlotte F. Belser, B.S. Dr. Malcolm Farrell Fernald State School Waverly, Massachusetts Dear Dr. Farrell: During the period January 24 through January 30, 1950 we collected slurries of food being served at the Fernald School and analyzed it for the nutrient value. The samples collected on each day were studied for thiamine, riboflavin, niacin and ascorbic acid content and the results were as follows: Table A: Thiamine Riboflavin Niacin Ascorbic Acid mg. mg. mg. mg. Jan. 24 1.181 1.511 14.15 96.0 " 25 1.418 1.572 8.45 86.5 " 26 1.536 1.771 14.95 93.9 " 27 1.042 2.636 10.09 180.4 " 28 1.144 1.817 13.33 93.2 " 29 1.201 1.656 19.13 110.2 " 30 1.280 1.856 13.24 93.4 Average 1.25 1.831 13.33 107.3 A composite of samples collected over the entire 7 day period was analyzed for these and other nutrients with the following results: B-20 2 Table B Results for Composite for Seven Days Constituent Amounts* per day N. R. C.Allowance 12-15 year old boy Moisture 2244.7 gm Ether extract 86.0 " Crude fiber 3.2 " Nitrogen 15.2 " 12.8 gm Ash 23.6 " Calcium 1017.0 mg 1300 mg Phosphorus 1800.0 " 1850 mg Iron 25.3 " 15. mg Carotene 3.18 " 5000 IU Thiamine 1.29 " 1.5 mg Riboflavin 1.83 " 2.0 mg Niacin 13.50 " 15.0 mg Ascorbic acid 108.8 " 190.0 mg *This was calculated on the basis of average weight of food for the seven days. In Table B we have listed the recommended dietary allowance of children as set up by Food and Nutrition Board of the National Research Council. You will note that the food being served at the Fernald School does pretty well in meeting these estimated requirements. Sincerely yours, (Signed Robert S. Harris) Robert S. Harris Professor of Biochemistry of Nutrition RSH:im B-21 MASSACHUSETTS INSTITUTE Of TECHNOLOGY CAMBRIDGE, MASS. DEPARTMENT OF FOOD TECHNOLOGY B. E. Proctor - Professor of Food Technology Head of Department May 1, 1953 R. S. Harris Professor of Biochemistry of Nutrition C. G. Dunn Associate Professor of Industrial Microbiology E. E. Lockhart Associate Professor of Food Chemistry H. Sherman Assistant Professor of Biochemistry of Nutrition J. T. R. Nickerson Assistant Professor of Food Processing S. A. Goldbitte Assistant Professor of Food Technology Dr, Clemens E. Benda Director of Research Walter E. Fernald State School Waverley 78, Massachusetts Dear Dr. Benda: As you know, we are planning to conduct a study to measure the availabilities of different calcium compounds in human subjects. In order for this study of five dIfferent calcium sources to be studied properly, we have planned an experimental design which will require fifteen subjects. On May Z9th Dr. Bronner spoke with Dr. Kelly regardIng the subjects and he stated that as of that time he had ten subjects lined up. On May 1st he indicated that three of these subjects objected to be included in the study and this reduced the number to seven. However, Dr. Kelly stated that five of the subjects who had previously received 1 microcurie of radiocalcium were willing to be used in this experiment. While we are delighted that these boys are willing, they will not be as satisfactory as fresh subjects because they have already received some calcium and we cannot give them 5 microcuries more. According to our experimental design, each subject will receive 1 microcurie on each of five experimental tests. We sincerely believe that this study is of very great clinical importance. We therefore hope that you will do everything possible to help us obtain a proper number of subjects for this experiment. It seems to me that the three subjects who objected to being included in the study can be induced to change their minds. It has been our experience that we need to round up about seventeen subjects if we hope to use fifteen in an experiment. If there is B-21 (cont.) 2 anything I can do to help in this please Iet me know. For instance, it occurs to me we have neglected the Fernald Science Club angle of our work and should line up a baseball game for the boys. Possibly it would be worthwhile for us to arrange an assembly so that we could tell the boys something about our work and get them to feel satisfied their smaI1 pain is really worthwhile. Sincerely yours, (signed) Robert S. Harris RSH:im B-22 FOR REFERENCE SEE (4bb13) NOTES B-23 May 28, 1953 Dear Parent: In previous years we have done some examinations in connection withthe nutritional department of the Massachusetts Institute of Technology, with the purpose of helping to improve the nutrition of our children and to help them in general more efficiently than before. For the checking up of the children, we occasionally need to take some blood samples, which are then analyzed. The blood samples are taken after one test meal which consists of a special breakfast containing a certain amount of calcium. We have asked for volunteers to give a sample of blood once a month for three months, and your son has agreed to volunteer because the boys who belong to this Science Club have many additional privileges. They get a quart of milk daily during that time, and are taken to a baseball game, to the beach and to some outside dinners and they enjoy it greatly. I hope that you have no objection that your son is voluntarily participating in this study. The first study will start on Monday, June 8th, and if you have not expressed any objections we will assume that your son may participate. Sincerely yours, Clemens E. Benda, M.D. Clinical Director Approved:____________________ Malcolm J. Farrell, M.D. Superintendent CEB:dfg B-24 SCIENCE CLUB BOYS - BH 6/5/53 (permission received June, 1953) (permission from father 11/6/49 WARD 22 6/5/53 (Dr. Weinberger over phone) Born Mental age IQ Weight 19-- 8o 71 116 lbs. 19-- 82 55 140 lbs. 19-- 72 59 112 lbs. B-24 FOR REFERENCE SEE (4bb14) NOTES B-25 June 29, 1953 Mrs.____________ ________________ ___, Massachusetts Dear Mrs. ________: We have heard that you plan to take your son __________ on vacation on July 1st. _______ is cooperating in a science test and it is extremely important that he be here on the 1st. and 2nd of July. Will you be good enough to change the beginning of ________ vacation from Wednesday, July 1st., to Friday July 3rd? If for any reason unknown to us this is not possible, please call me or my secretary at Waltham 5-3600 immediately after receiving this letter. Thank you. Sincerely yours, Clemens E. Benda, M.D. Clinical Director Approved: ______________________ Malcolm J. Farrell, M.D. Superintendent CEB/dfg B-26 ANNUAL REPORT OF THE RESEARCH LABORATORY WALTER E. FERNALD STATE SCHOOL WAVERLEY 78, MASSACHUSETTS July, 1952 - June, 1953 B-26 (cont.) The research activities of the Department covered a larger field of investigations than in previous years, due to the fact that more and more research has been done along clinical and biological lines in connection with different research departments in the Boston area. The main research at the Department of the Walter E. Fernald School is still centered around research in neuropathology of mental disorders. There were 15 autopsies performed between July 1, 1952, and June 30, 1953. These 15 autopsies out of 30 deaths represent a percentage of 50 per cent, which appears quite satisfactory. The material of these autopsies was prepared for microscopic study, and in many instances hundreds of serial sections were made to have a complete picture of the underlying pathology and, at the same time, satisfactory material for teaching purposes. It is interesting to note that in contrast to previous years, only one mongoloid was among these cases whereas 4 cases were hydrocephalics, 3 microcephalics, and the others mainly cases of brain injury with different forms of brain damage and cerebral palsy. The material on hydrocephaly was worked up and partly used in a presentation given at the meeting of the American Association of Neuropathologists in Atlantic City on June 14, 1953. The title of the paper was: "The Dandy-Walker Syndrome or the So-called Atresia of the Foramen Magendie." This paper will be published in a memorial issue for the late Dr. Joseph Globus which will be issued by the Journal of Neuropathology and Experimental Neurology, probably in January, 1954. Research in mongolism has been continued and new results have been presented at a Symposium on Mongolism held at the Jewish Hospital in Brooklyn, New York, on February paper. This paper has been published in the May issue 2 B-26 (cont.) of the QUARTERLY REVIEW OF PEDIATRICS under the title, "Research in Congenital Acromicria (Mongolism) and its Treatment." The research in mongolism moved from neuropathological research to biochemical research. A study of the protein-bound-iodide in mongolism is at present carried out in cooperation with the Massachusetts General Hospital, Thyroid Laboratory. These studies are of extreme significance in order to gain more insight into the function of the thyroid in mongolism. At the same time, a number of patients have been studied with I131 at the Thyroid Laboratory of the Beth Israel Hospital, in order to study the up-take of the thyroid. In order to get more insight into adrenal and pituitary function, a study of eosinophilic reactions was carried out, mainly by Dr. Bowman with the assistance of Mr. ____, making eosinophilic counts in mongoloids before and after application of ACTH and adrenalin. The result of this study is included in the publication, "Research in Congenital Acromicria (Mongolism) and its Treatment." Another line of investigation is being done with Dr. George Mann of the Harvard School of Public Health, Department of Food Research, to determine cholesterol molecules which have been reported as abnormal by Dr. John Gofman and his co-workers at the meeting of the American Psychiatric Association in Los Angeles, California, May 8, 1953. This paper was discussed by Dr. Benda and Dr. Farrell at that meeting, Dr. Farrell presenting the discussion. Our own studies concerning the different cholesterol molecules were carried out in a way that the blood of 21 mongoloids and 21 control cases, matched by chronological and mental ages, was sent in to Dr Mann's laboratory without attached diagnosis and the blood was analyzed in order to see whether significant differences could be detected. In this study, mongoloids of an age B-26 (cont.) 3 between 16 and 30 were studied because we considered it of interest to see whether there is an inherent metabolic disturbance present in mongolism which would appear in the fat metabolism even in younger age groups. The preliminary results of this study seem to indicate that this is not so. There may, however, be an inherent tendency to abnormal metabolism which becomes more and more obvious as age progresses, and we shall now study an older age group to see whether significant changes will occur with increased age, which would, of course, be also a result of extreme importance. Another line of investigations is proceeding with regard to calcium metabolism. This research is carried out with the Department of Food technology at the Massachusetts Institute of Technology under the direction of Professor Robert S. Harris and a coordinating investigator, Dr. Felix Bronner. In this study, different calcium preparations and types of meals are used to study the calcium absorption from food by means of Ca45. These studies are of great interest for many reasons. Calcium metabolism is still fairly unknown and the ways of absorption, storage and excretion are only insufficiently established. The present study promises to permit a set of very definite scientific data which will settle a number of arguments. Another experimental study is carried out with feeding and mating experiments on rats and mice, which are fed with food deficient in certain properties. The animals are observed clinically in developing certain deficiency symptoms, and a number of them are then sacrificed and studied anatomically. Some of the surviving animals have been used for mating experiments because the anatomical studies have shown definite evidence that the gonadal system is very susceptible to deficiency diseases and abnormal sperm cells occur readily. For the field of mental deficiency, it is therefore of great interest to study whether the offspring of food-deficient animals shows a higher percentage of malformations B-26 (cont.) 4 and fetal deaths. As for as the present study goes, the data at hand seem to prove this point. Teaching and educational activities at the Research Department have increased steadily during the last year, and the load of teaching obligations has been increasingly felt. During the past year the National Institute of Mental Health has continued the grant for training in psychiatry, which position was filled by Dr. Peter W. Bowman. Dr Bowman spent most of his time at the Research Laboratory, participating actively in the research, and in the Outpatient Clinic. There have been a great many visitors to the Research Department, who wanted to see what kind of research is done in mental deficiency and to learn about the basic facts. The staff of the Research Laboratory consists of the following: The secretary; Mrs. _______, who has done a great amount of work beyond the usual capacities of one secretary so that it was not necessary to engage a part-time second secretary during the last year, as has been done in previous years. On account of her unusual efficiency, it was voted in March, 1953, to augment her salary by an additional $10 a month, to make up at least partly the difference between her salary as a State employee and the salary of a Federal secretary which had been offered her on different occasions. The Tissue Laboratory employs Mrs. _____ and Miss ______, Mrs. ___ has been shifted to the State employee roll and receives, therefore, only a small additional sum to make up for the salary to which she would be entitled according to her long years of service and efficiency. The salary of Miss ________ has been increased after a year of service at the Research Laboratory. B-27 September 29, 1953 Atomic Energy Commission Isotopes Division P. O. Box E Oak Ridge, Tennessee Attention: Sub-Committee on Human Applications Gentlemen: This letter is written in order to elicit your permission to administer a dose of 50 uc Ca45 to a UNREADABLE gargoyle patient now hospitalized in our institution. _____________ Diagnosis: Gargoylism (Chondrolipodystrophy). (See Clemens E. Benda: DEVELOPMENTAL DISORDERS OF MEDITATION AND CEREBRAL PALSIES, 1952, Grune & Stratton, New York.) The patient in a child of ___ years, suffering from this severe metabolic disorder since birth but going progressively downhill at present. There is no doubt about the diagnosis, which in confirmed by clinical studies and X-ray studies. Children who develop this metabolic disorder early in life usually die before they reach an age of 10 and not more than 15 years. This patient has been an especially severe condition for the last year, and his life expectancy is now limited to a few months. For this reason I respectfully urge prompt consideration of this application. It will be appreciated if you will notify me at once if this request cannot be acted upon promptly. I have been conducting studies on the Ca45 metabolism of mentally deficient patients in cooperation with Drs. B. S. Harris and F. Bronner of the Massachusetts Institute of Technology for the past 3 1/2 years. Permission for the use of small quantities of radiocalcium is contained in Authorization No. 13974, dated May 8, 1952, and Authorization No. 18444, dated March 10, 1953. Permission for the use of higher doses administered to UNREADABLE patients has been granted by you to other investigators, as evidenced by the report of Sellin and Lasslo (Science, 117,331-4, 1953.) In view of the foregoing it is my hope that you will consider this request favorably. Respectfully yours, Clemens E. Benda, M.D. Director of Research and Clinical Psychiatry CEB/dfg B-28 October 6, 1953 _____________ _____________ Boston, Mass. (Apartment __) Dear Mrs. __________: We cannot find that we have ever received a reply to our letter of August 7th, asking permission for your son to participate in examinations in connection with the nutritional department of the Massachusetts Institute of Technology. As stated in that letter, the tests are made for the purpose of improving the nutrition of our children and, in general to help them more efficiently than before. _______ has expressed willingness to participate in this project and we would greatly appreciate it if you would sign the enclosed permission and return it at your earliest convenience. Sincerely yours, Clemens E. Benda, M.D. Director of Research and Clinical Psychiatry Approved: _______________________ Malcolm J. Farrell, M.D. Superintendent CEB/dfg Enclosure B-29 MASSACHUSETTS INSTITUTE OF TECHNOLOGY CAMBRIDGE, MASS. __________ DEPARTMENT OF FOOD TECHNOLOGY B. E. Proctor - Professor of Food Technology Head of Department December 2, 1953 R. S. Harris Professor of Biochemistry of Nutrition C. G. Dunn Associate Professor of Industrial Microbiology E. E. Lockhart Associate Professor of Food Chemistry H. Sherman Assistant Professor of Biochemistry of Nutrition J. T. R. Nickerson Assistant Professor of Food Processing S. A. Goldbitte Assistant Professor of Food Technology Dr. Malcolm T. Farrell, Superintendent Walter E.Fernald State School Waverley, Massachusetts Dear Dr. Farrell: As in the past years, we again would like to give a Christmas party to the boys of the Science Club who cooperated with us during 1953. We have arranged for a dinner party to be held at the M. I. T. Faculty Club, 50 Memorial Drive, Cambridge, at 5:30 P. M. on Wednesday, December 16, 1953. We would very much like to have you, Dr. Benda, and Dr. Kreplick join us in this festivity. For your convenience we are enclosing a list of the boys who participated in the studies this past year. We would appreciate your letting us know at an early date whether the date suggested is Convenient, whether all of the boys will be able to come, and how many attendants will accompany them. There is ample parking space in the back of the Faculty Club, off Wadsworth Street. The Club is located on the sixth floor but one of us will meet the group on the ground floor. Cordially yours, Robert S. Harris Felix Bronner, Ph.D. Research Associate RSH:im Enclosure B-30 FOR REFERENCE SEE (4bb18) Graphic B-30 (cont) FOR REFERENCE SEE (4bb15) Graphic B-31 GRAPHIC THE COMMONWEALTH OF MASSACHUSETTS DEPARTMENT OF MENTAL HEALTH Malcolm J. Farrell, M.D. Superintendent WALTER E. FERNALD STATE SCHOOL BOX C, WEAVERLY 78, MASS. October 18, 1955 Dear Miss ____________ We wrote to you on September 12th about some planned research in conjunction with the Nutritional Department of the Massachusetts Institute of Technology, and asked that you sign the permission slip for the participation of your son in this project. Most of the parents have given permission for their sons to participate, and we would appreciate receiving a definite answer, either "yes" or "no", since the studies UNREADABLE to be started soon. Sincerely yours, Clemens E. Benda, M.D. Clinical Director Approved ____________________ Malcolm J. Farrall, M.D. Superintendent CEB/dfg B-32 GRAPHIC THE COMMONWEALTH OF MASSACHUSETTS DEPARTMENT OF MENTAL HEALTH 15 Ashburton Place, Boston 8 June 1, 1956 FROM: Commissioner TO: Superintendent Dear Doctor: The Governor and some members of the Legislature expressed interest in the kinds of research going on in our institutions. Since it has been approximately 18 months since we conducted such a round-up I would like to have the following information within the next ten days: A paragraph, not more, on each research project in your place. The paragraph should contain the following information. The kind of project, for example, biochemical studies in schizophrenia, with a statement whether it involves protean or other factors or another example might be sociologic studies on the role of ______and______. I should like to know approximately the number of persons involved in it and the number of patients involved. A brief statement as to about when this project will be completed and the hypothesis being tested. I don't want a detailed report of the progress of the study I only want to know what's going on and what its general purposes are. I believe this will prove advantageous to us in structuring next years budget. Sincerely yours, (signed) Jack R. Evalt, M.D. Commissioner JRE:MIM