ATTACHMENT 2






SECURITY INFORMATION CONFIDENTIAL

COMMITTEE ON MEDICAL SCIENCES 
RESEARCH AND DEVELOPMENT BOARD
DEPARTMENT OF DEFENSE
WASHINGTON 25, D.C.

15 December 1952
BAW 113/1 COVER

DECLASSIFIED 
Authority NWD 813070
By             2/7/94

MEMORANDUM FOR CHAIRMAN AND MEMBERS, JOINT PANEL ON THE MEDICAL ASPECTS 
OF ATOMIC WARFARE

SUBJECT:  Department of Defense Research Program under the Tehnical 
Objective of AW-6

l.   Attached is a digest of Army, Navy, Air Force and AFSWP research 
projects, including their fiscal support, under the Technical 
Objective AW-6. In addition, there is a supplemental list of studies 
supported by the Public Health Service and the Atomic Energy 
Commission.  The digest of projects supported by the services is 
intended to be complete as of September 1952; the list of the studies 
of the Public Health Service and Atomic Energy Commission is not.

2.   The Purpose.  This digest is intended to indicate the intensity 
of research effort in relation to the Program Guidance Report of the 
Panel. Admittedly this indication can only be crudely made in terms of 
the subject titles, the experimental purpose, and the fiscal support 
of the research projects.

3.   The Source.  The descriptive information on the service supported 
projects was obtained from IA Forms.  The information has the same 
limitation as those forms.  It is not meant to accurately nor 
completely describe the actual current work of the laboratory.

4.   The fiscal information was obtained from several sources: 
Resources Division, RDB; Army Medical Research and Development Board; 
US Navy Bureau of Medicine and Surgery; Air Research and Development 
Command; Surgeon's Office, AFSWP; National Research Council Medical 
Information Exchange; Division of Biology and Medicine, AEC; National 
Institutes of Health.


THIS DOCUMENT CONTAINS INFORMATION AFFECTING THE NATIONAL DEFENSE OF 
THE UNITED STATES WITHIN THE MEANING OF THE ESPIONAGE LAWS, TITLE 18, 
U.S.C. SECTIONS 793 AND 794.  THE TRANSMISSION OR THE REVELATION OF 
ITS CONTENTS IN ANY MANNER TO AN





UNAUTHORIZED PERSON IS PROHIBITED BY LAW.






B&W 113/1 COVER

     5.   The fiscal information is for FY 1953 unless indicated.


JOHN D. STOECKLE
1st Lt., MC, USAR
Panel Director
Committee on Medical Sciences

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SECURITY INFORMATION CONFIDENTIAL

BAW 113/1

SUMMARY

1.   Fiscal Support for the Technical Objective AW-6.  The overall 
support of research programs under AW-6 for FY 1953 is 14% of the 
total medical research budget of the three services.  The funds 
obligated, planned or estimated in this technical objective since its 
establishment as a research category have been:*

1949           $897,000            (Obligated)
1950           1,135,014           (Obligated)
1951           2,409,000           (obligated)
1952           3,792,000           (obligated)
1953           4,009,000           (Planned)
1954           4,440,000           (Estimated)

2.   Fiscal Support of the Research Program in Subject Fields of the 
Technical Objective AW-6:**

Project                                                Total
BURNS
Army (6-59-08-004, 6-59.12~21)          $751,000
Navy (NM 006-012.02, NR 114-00)         241,000
Air Force
AFSWP (l-08-51, other than funds        147,600   $1,139,000
       under NR 114 000)

RADIATION
Army (6-59-08-013, 6-59-08-005)         502,000
Navy (NM 006-012.04-6,                  1,052,400
NM 006-015.04-5, NR 117-000, NR 182-000)
Air Force                               620,000
AFSWP (1-09-51)                         100,000
                                                  2,304,400

BLAST
Army
Navy (NM 006-12.01)                     66,000
Air Force
                                                  66,000


*    Resources Division, RDB
**   See Memorandum for Sources

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SECURITY INFORMATION CONFIDENTIAL
BAW 113/1

OTHER
     Army (Blood and Blood Derivatives,      $1,009,000
     6-64-09-001; Plasma Volume expanders,
     6-59-12-024; Intravenous Fat,
     6-60-11-014; Sterilization of Blood
     6-59-12-025)                                 $1,009,000

3.   Fiscal Support of the Subject Fields of AW-6 in Medical 
Laboratories of the Army, Navy, and Air Force:
                              

                    BURNS     RADIATION      BLAST     OTHER
Army Laboratories   
AMRL, Ft. Knox                200,400
AMC, Walter Reed    $50,000   110,000                  $30,000
SRU, San Antonio    122,623

Navy Laboratories
NMRI, Bethesda      33,000    231,000        $66,000
NRDL, San Francisco 147,600   780,400

Air Force Laboratories
USAF Radiation Lab, Chicago   250,000
USAF Radiobiological Laboratory
 (Not active)
  Bedford, Mass.
School of Aviation Medicine,  Undeter-       Undeter-
 San Antonio, Texas            mined         mined



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SECURITY INFORMATION CONFIDENTIAL



BAW 113/1                               15 December 1952

OFFICIAL DIGEST OF ARMY, NAVY, AIR FORCE AND 
AFSWP PROJECTS UNDER TECHNICAL OBJECTIVE AW-6

PROJECT NO.    
SUBJECT, DESCRIPTION AND INVESTIGATOR   
FUNDS

6-59-08-004

Radiation and thermal Burns.  E.I. Evans, Medical College of Virginia.  
Project is designed to investigate the traumatic, thermal and 
radiation types of injuries expected to result from atomic explosions, 
and to develop optimum and practical methods of treatment.
210,000

6-59-08-005
Ionization Effects
(1) Army Medical Service School.  At ANSGS experimental work is being 
done on use of radioactive iodine as a diagnostic procedure, use of 
F32 in blood volume determinations and treatment of metastatic 
carcinoma, effects of anti-biotics on the radiation syndrome, the 
measurement of oxygen intake of the marrow before and after 
irradiation, and the influence of weaning, age, weight, sex and 
endrocrine patters on radiation mortality in mice, etc. (2) J.G. 
Allen, University of Chicago.  Work done on treatment of radiation 
sickness with blood transfusions, on clotting defect on radiation 
injury, etc.
$65,282

6-59-08-013    Effects of Irradiation
(1)  Radiation Injury.  E. Pendergrass, U. of Pennsylvania. Project is 
to investigate biologic effects of irradiation with emphasis on 
protection.  Bio- and histochemical methods have been used to 
determine --SU groups in testicular hormogenates before and after 
irradiation, along with methods for the quantitative analysis of other 
enzymes.  Studies of the mechanism of protective effects of pitressin, 
para-amino-propiophenome, bone marrow injunction, and later effects of 
irradiation on the skin are in process.
$25,000


THIS DOCUMENT CONTAINS INFORMATION AFFECTING THE NATIONAL DEFENSE OF 
THE UNITED STATES WITHIN THE MEANING OF THE ESPIONAGE LAWS, TITLE 18, 
U.S.C. SECTIONS 793 AND 794.  THE TRANSMISSION OR THE REVELATION OF 
ITS CONTENTS IN ANY MANNER TO AN





UNAUTHORIZED PERSON IS PROHIBITED BY LAW. 





PROJECT NO.    
SUBJECT, DESCRIPTION AND INVESTIGATOR   
FUNDS

6-59-08-113 (Contd)
(2) Pathological Study of the Central Nervous System. National Academy 
of Sciences.  Project is to conduct a pathological study of the 
Central Nervous System of irradiated humans and experimental animals.  
W. Haymaker, Armed Forces Institute of Pathology.
$26,500

(3)  Effects of Irradiation. Army Medical Research Laboratory, Ft. 
Knox, Kentucky.  Project is studying the effects of irradiation on 
cells by histochemical and vital staining techniques, alterations in 
endocrine function in animals receiving whole irradiation, changes in 
enzyme systems, and spectral reflectance of the skin.
$200,400

(4)  Radioactive Tracer Studio. G. Burch, Tulane University School of 
Medicine.  Potassium metabolism is being studied by use of radioactive 
rubidium.
$6,000

(5)  Effects of Ionizing Radiation on Erythrocytis. M.A. Lessler, Ohio 
State University.  Terminated 1953. (1952)
$14,508

(6)  Radiation affects. V. P. Collins, Columbia University, Collage 
Physicians and Surgeons.  Project will control the total body 
irradiation in humans with bone marrow depression as reflected in 
plasma iron turn over rate. Completed 1952.
$5,090 AFSWP (1952)

(7)  Analysis of Indirect Effect of Radiation. P.F. Salisbury, Cedars 
of Lebanon Hospital. Dogs will be exposed to standard lethal dose of 
radiation.  The test animal all then be cross transfused with normal 
togs.  The following factors will be varied. Time interval between 
irradiation and treatment, rate, and amount of blood exchanged, age of 
animals.

6-59-12-021         THERMAL BURNS

(1)  Thermal Burns.  H.S. Allen, Northwestern University.  This is a 
comparative clinical study of the "exposure method" and the "closed 
method" of treatment.  The time course for natural recovery of the 
plasma proteins and the anemia, as elated to the size and severity of 
burns, will be determined.  This will be used to determine optimum 
time for transfusions and protein replacement.
$10,500
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6-59-12-021
Experimental and Clinical Study of Cutaneous Burns. W.A. Altmeier, 
University of Cincinatti College of Medicine. Control of burn 
infections by means of protolytic enzymes and antibiotics is being 
studied.  Attempts are made to develop practical ways of handling 
fractures with overlying severe thermal burns.  A proteinase had been 
produced from cultures of Cl. Histolyticum.  This is effective in 
removing eschars in guinea pigs. Bacterial cell wall suspensions are 
being made in order to make chemical analyses and to detect a 
difference between sensitive and resistant strains of bacteria.
$30,000

(3)  Tissue Culture Studies in Relation to Thermal Injury. T.G. 
Blocker, University of Texas, Galveston.  Toxic factors in irradiation 
tissue which retard healing are studied by extracting burned tissue at 
intervals after burning and testing the extracts on epithelium growing 
in tissue culture.  Attempts will be made to determine the ideal 
conditions for the growth of human skin.  exposure method of treatment 
has been successfully applied to burns.
$29,000

(4)  Thermal Burns.  O. Cope, harvard Medical School.  Noted under NR 
114-000.198.

(5)  Burns Involving the Respiratory Tract. J. Conroe, University of 
Pennsylvania.  Objectives are to define the nature of direct and 
reflex effects of heat and combustion products on the respiratory 
passages, to devise methods for the early diagnosis of damage to the 
lower respiratory tract, and to determine methods of treatment.
$15,000

(6)  Renal Dysfunction Following Thermal Injury.  M.E. DeBakoy, Baylor 
University.  Objective is to do urea, para-amino hippurate, inulin, 
and radioactive sodium clearances in burned animals and humans and to 
correlate thse studies with renal blood flow and urinary output, in 
order to determine the extent of renal dysfunction following thermal 
injury.
$13,000

(7)  Treatment of Fractures Complicated by Burns.  The purpose of this 
project is to study the treatment of open and closed fractures 
complicated by contiguous burns.  Plaster immobilization will be 
compared with internal fixation.  W. Fitts, University of 
Pennsylvania.
$13,000
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6-59-12-021 (contd)
(8)  Burns of Respiratory Tract.  J. Gibbon, Jefferson Medical 
College.  The object is to determine the value of a nonmechanical 
heart-lung apparatus in the treatment of pulmonary edema following 
burns of the respiratory tract.
$17,000

(9)  Transplantation of Skin. H. Green, Yale University.  Using the 
anterior chamber of the eye a study will determine what factors make 
homologous skin transplants grow.
$16,000

(10)  Debridement of Thermal Burns. E. Howes, Columbia University.  
The proteolytic enzymes, collagenase and pseudocollagenase, elaborated 
by clostridial bacteria will be concentrated, purified and tested for 
their value in removing slough from deep thermal burns.  Methods for 
producing enough of the most promising enzyme to make clinical trials 
possible will be developed.
$31,500

(11) Burns Involving the Respiratory Tract.  C. Schmidt, University of 
Pennsylvania.  Project will study respiratory tract burns with 
emphasis on pulmonary edema, laryngespams and the influence of drugs 
on these conditions.
$16,000

(12) Thermal Burns.  J  D. Hardy, University of Tennessee.  A clinical 
and laboratory study of the cause of death in thermal burns will be 
undertaken.
$19,000

(13) Debridement of Thermal Burns. E.T. Krementz, Tulane University 
Medical School (AFSWP) Project is investigating inositol phosphatide 
on separation of slough and the rate of epithelialization of a 
standard burn.  Completed 1952.
$21,000

(14) Burns and Chronic Infected Wounds. L.M. Rousalot, St. Vincent's 
Hospital, NYC.  Clinical evaluation of the proteolytic enzymes, 
streptokinase and streptodornase, for control of infection and removal 
of slough an debris from burns and infected wounds in being done.
$21,000

(15) Reversible Electrolyte Imbalance in Shock.  J.M. Walker, 
University of Pennsylvania.  The purpose is to determine the cause of 
death with high plasma NPN.  A study will be made of critical fluid 
shifts in brain, kidney, and heart.
$28,000
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6-59-12-021 (contd)
(16) Treatment of Thermal Burns.  C. Walter, Peter Bont Brigham 
Hospital.  The object is to study the use of artificial kidney in 
treating cases of acute renal failure due to thermal burns and in 
investigating the cause and mechanisms of burn toxemia and renal 
failure.
$50,000


(17) Effects of Vasoactive Substances. A. A. Schiller, College of 
Medicine, University of Illinois.  Will study effects of extracts of 
burned skin on cutaneous circulation.
$6,000

(18)  Surgical Application of Bacterial Enzymes.  B.S. Walker, Boston 
University.  Proposed to isolate from bacterial sources enzymes 
hydrolyzing proteins, mucopolyscharides and collagen, and to 
investigate the hemostatic action of staphylococcal procoagulase.
$18,000

(19)Burns Involving the Respiratory Tract. J.I. Whittenberger, Harvard 
University.  The purpose of this study is to define the sequence of 
physiologic events following injury of the respiratory tract, as a 
basis for appropriate therapy.
$8,617
          
(20)Thermal Burns. Surgical Research Unit, Brooke Army Medical Center.  
This study is evaluating, developing and perfecting techniques for the 
care of personnel exposed to thermal radiation.
$122,623

(21) Burn Therapy.  Army Medical Service Graduate School, Washington, 
D. C.
$50,000

6-59-12-24     PLASMA VOLUME EXPANDERS

(1)  Dextran. W. Bloom, Emery University. Project is investigating the 
fate and possible metabolism of dextran in vitro and in vivo and its 
clinical effects in patients.
$20,000

(2)  Blood Plasma Expanders. E. Blount, Children's Medical Center, 
Boston.  This investigator will synthesize water-soluble high polymers 
from naturally occurring alpha-amino acids for possible use as plasma 
expanders.  The pharmacologic and physiologic properties of each will 
be tested.
$36,368 (1954)
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6-59-12-024 (contd)

(3)  Plasma Expanders.  A. Gournand, Columbia University.  This is a 
clinical study of the effects of various plasma substitutes on the 
circulation in cases with peripheral circulatory collapse due to 
trauma, hemorrhage, or other causes.
$10,000

(4)  Polyvinalpyrrolidone. E. Elrich, Polytechnic Institute of 
Brooklyn.  The objective is to determine physical and chemical 
constants of individual samples of PVP with a view to correlating them 
with data from physiologic and clinical investigations, and to study 
its state in solution in order to connect molecular structure with 
clinical effects.
$25,000

(5)  Dextran.  L. Flexner and F. Chinard, Carnegie Institute of 
Washington.  The purpose of this study is to investigate the decrease 
in the plasma levels of dextran and the uptake of this material by 
various organs of the body, and the effects on blood volume and 
distribution of water between the extravascular and vascular 
compartments.  Completed.
$6,550 (1951)

(6)  Plasma Expanders. L. Hellman and D. Becker, Sloan Kettering Inst. 
for Cancer Research.  The purpose is to study C 14 labeled plasma 
expanders.
$16,000

(7)  Effects of Plasma Expanders.  L. Roussalot, St. Vincent's 
Hospital, N.Y.  This project will investigate the dehydrating effects 
of plasma in expanders and will measure the water displaced from 
tissues into the circulation in normals and patients in shock.
$12,000

(8)  Plasma Colloid Expanders. H.W. Vars, University of Pennsylvania.  
Oxypolygelatin is studied to determine its toxicity, blood levels, and 
effects of long continued administration.  Fluid of long continued 
administration.  Fluid gelatin is also studied.
$47,000

(9)  Plasma Expanders.  S.G. Weissberg, National Bureau of Standards.  
Plasma expanders will be characterized chmically and physically for 
purposes of developing control and inspection methods.
$60,000






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6-59-12-024 (contd)
(10)  Plasma Expander Material.  J.W. Wiiliams, University of 
Wisconsin.  Project is investigating the distribution of molecular 
sizes in commercially available iv gelatin solutions.
$15,000

(11)  Synthetic Colloids. R. Zollinger, Ohio State University.  
Comparative evaluations of the plasma expanders in human  patients are 
being made.
$30,000

(12) Dextran.  Army Medical Service Graduate School, Washington, D. C.  
Attempts will be made to develop more suitable methods for 
microanalysis of dextran in blood. Clinical studies are also done.
$30,000

(13) Periston. J. Fine.  Harvard Medical School.  This work will 
evaluate Periston as a blood substitute.
$31,000

(14) Evaluation of Plasma Expanders. Surgical Research Unit, Brooke 
Army Medical Center.  This unit is testing plasma expanders in animals 
and humans with attention to safety, reactions, efficiency in 
restoring blood volume.  Metabolism, excretion and retention are 
studied.
$80,000

(15)  Plasma Volume Expanders.  P. B. Beeson, Emery University.  Work 
is done to determine the relationship between molecular size and 
Schwartzman activity of hydrolyzed fractions of dextran and 
correlation with leukopenia-producing capacity.
$6,000

(16) Plasma Volume Expanders. J.M. Neill and E.J. Hehre, Cornell 
University.  The immunological properties of "native" and of partially 
hydrolyzed dextrans will be studied using a variety of products from 
several sources. The occurrence and reacting capacities of non-dextran 
constituents of dextran-forming bacteria in culture fluids will be 
determined.
$17,000

(17) Plasma Volume Expanders. L. Pauling and D. Campbell, University 
of California.  This project conducts chemical studies of 
oxypolygelatin to provide for basis for improvement of the product and 
for interpreting the findings of biological studies.

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BAW 113/1

6-59-12-024 (contd)

(18) Tissue Culture Studies. J. Szepsenwol, Emery University. A study 
of effects of plasma expanders on graph of embryonic tissues in vitro. 
$11,000

(19) Plasma Expanders.  R. C. Warner, New York University. Develops 
analytical methods for measuring the plasma expanders in body tissues, 
fluids, excreta, and determines the effect of plasma expanders on 
reliability of standard methods for blood analysis for cell and plasma 
volume determinations.
$149,295 (1951)

(20) Plasma Expanders. F.D Larason, National Academy of Sciences.  A 
central information office for all phases of plasma expanders program 
has been set up.
$149,295 (1951)

(21) Effect of Polyvinvlypyrrolidone on Protein Excretion.  S.E. 
Bradley, Columbia University. Study is measuring the effects of kidney 
functions of a variety of types of PVP of different molecular sizes to 
determine which types and molecular sizes are excreted by the normal 
and nephatic human kidney.
$13,486

(22) Physiological and Biochemical Studies with Plasma Expanders. The 
effect of various plasma substitutes including dextrans will be 
studied both in animals and in patients.  R. Elman, Washington U., 
School of Medicine.

(23) Dextran. P.H. Maurer, University of Pittsburgh.  Antigenic 
properties of dextran will be studied.
$5,000

(24) Plasma Expanders. S.M. Horwath, State University of Iowa,  
Effects of plasma expanders and polyglucose on cardiac output, liver 
blood flow, renal functions, arterial and venous blood pressures, 
blood volume, body water, body weight, appetite and blood composition 
will be studied.
$10,000

(25) Dextran and Periston. T. S. Danowski, University of Pittsburgh. 
Dextran and PVP will be studied in animals which have salt depletion 
type of shock and in patients with this and other shock states.  12 
and 24% dextran will also be studied.
$17,000

(26) Non-protein Colloid Solutions.  J. Peters, Yale University.  
Studies the effect of plasma expanders on excretion of water on 
electrolytes in normal humans and in edematous patients.  $4,000
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BAW 113/1

6-59-12-025
STERILIZATION OF BLOOD AND BLOOD DERIVATIVES

(1)  Chemical Corps Medical Laboratories.  Toxicity studies in animals 
using blood treated with chemical agents which have exhibited 
promising virucidal properties, i.e, sulfur, mustard and B. 
propriolactone, will be carried out.
$20,000

(2)  Dr. R. Murray. National Institute of Health.  The aim is to 
critically evaluate the methods now used or proposed to sterilize 
human blood and derivatives, with particular emphasis on the problem 
of serum hepatitis. (3) A.P. Richardson, Beta Propiolactone study.
$5,980

6-60-11-0l4
FAT EMULSION FOR INTRAVENOUS NUTRITION
(1)  Fat Emulsions for IV Nutrition. J.B. Youmans and H.C. Meng, 
Vanderbilt University.  A fat has been synthesized with view to 
producing one of composition somewhat resembling human.  Dextran has 
been used as a co-emulsifier along with others previously used, 
phosphatides, Span 20, etc., and found to produce a finer homogenous 
product.  Study of the "synthetic fat" on weaning rats is in progress.  
More work will be done on making the fat fulfill ideal 
characteristics.  Also supported by PHS, $6,642.
$15,000

(2) Fat Emulsions for IV Nutrition.  F. Starc, Harvard Medical School.  
The purpose of this study is to improve the techniques of production 
of fat emulsions, to extend clinical studies on the values of fat, 
i.e., in burns, trauma, pre-and post-operative care, and attempt to 
combine protein and vitamins with fat emulsions to give complete 
parenteral feeding mixture.  Also supported by PHS, 15,000.
$35,000

(3)  IV Fat Emulsions.  J. Fine, H. Seligman, L. Fieser, Harvard 
Medical School.
$42,000

(4)  Ultrasonic Emulsification. W. Roth and S. Rich, Rich-Roth 
Laboratories, East Hartford, Connecticut.
$14,000

6-64-01-009    BLOOD AND BLOOD DERIVATIVES

(1)  Chemistry of Blood Coagulation.  B. Alexander, Harvard Medical 
School.  The aims of this work are to purify and study the properties 
of prothrombin and SPCA.  $16,000
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6-64-0-009 (contd)
(10) Isolation of Prothrombin , Prothrombin Activators and Platelets. 
J. Milstone, Yale University.  Electrophoretic analyses are made of 
various fractions and their purified derivatives to detect unsuspected 
impurities.  Lyophilized pro- thrombim and Howell's thromboplastin 
preparations are being made.  The objectives will be to isolate and 
crystallize coagulating factors for clarification of the coagulation 
theory.
$24,000

(11) Intravascular Clotting. J.H. Olwin, Presbyterian Hospital, 
Chicago.  Project is to evaluate the presently available methods and 
attempt to develop new methods for measuring known coagulation factors 
of blood.
$31,500

(12) Formed Blood Elements.  I.S. Ravdin, University of Pennsylvania. 
Work is done to lengthen the store life of erythrocytes, leukocytes 
and platelets of blood by immediate separation by centrifugation and 
to attempt to find optimum preservative fluids for resuspension.  The 
viability of elements will be determined.
$17,000

(13) Blood Coagulation. C.L. Schneider, Wayne University College of 
Medicine.  Project is studying the initiation of blood coagulation 
with emphasis on platelets and on the platelet accelerator, the factor 
in platelets which influences the interaction of thrombin and 
fibrinogen.
$17,000

(14) Preservation of Blood for Transfusion.  M. Strumia, Bryn Mawr 
Hospital, Bryn Mawr, Pa. Studies are to determine the causes for the 
deterioration of cellular elements of whole blood in storage and 
transport, and to slow the metabolic aging and destruction of cells to 
a minimum by improving the preservation fluids and by other means.
$28,000

(15) Clot-Accelerating Properties of Orally Ingested Fat. J.M. 
Waldron, University of Pennsylvania.  This is a study of the above 
topic.

(16) Blood Coagulation.  A. Jare, University of Southern California.  
Isolation, purification and determination of the properties of 
accelerator globulin and anti-thromboplastin is being done.
$16,000

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6-64-01-009 (contd)

(17)  Leucocytic Extracts. M. Strumia.  The effect of crude Leucocytic 
extract and fresh plasma on bone marrow regeneration and on the 
mortalities rate of experimental animals decreasing total body 
irradiation.
$26,000

(18) Blood coagulation. D. F. Waugh, Massachusetts Institute of 
Technology.  The structure of the fibrin clot and the effect of ionic 
strength, pH, etc., on the clot is studied.  Attempts are being made 
to determine the quantitative effects of various clot accelerators and 
inhibitors and their modes of action.
$10,000

(19) Preservation of Human Erythrocytes. C. Walter, Harvard Medical 
School.  Project is a study of preservation of human erythrocytes at 
minus 10 to minus 15 degrees C in an effort to increase blood bank 
storage time.
$12,000

(20) Plastic Blood Equipment.  Medical Research and Development Board.

(21) Alterations in Fibrinosen Induced by Ultra Violet Irradiation.  
B. Burbank, College of Medicine State University of New York, New 
York, New York.
$2,000

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NM 106-012     
Medical Defense Aspects of Atomic Warfare.  Naval Medical Research 
Institute, Bethesda.  This project has five subtasks:
$330,000 Total

.01  Blast Studies.  Objective is to develop equipment for simulating 
the atomic bomb air blast and to study the nature of such injuries in 
animals.  $66,000

.02 Thermal Burns.  Investigations are concerned with design and 
construction of thermal radiation generator study of simulated atomic 
bom radiation injuries, prevention of sludging of blood in burns, 
analysis of pathologic processes in burns, and design of equipment for 
the exposure of animals during atomic weapon's field test.  $33,000

0.4  Biological Effects of Radiation. Investigations include the 
design and construction of radiocobalt large animal irradiator, 
mathematical analysis of experimental and field data, determination of 
lethal dose of total body x-radiation in swine, the study of lymph in 
irradiated dogs, the pathological sequence in mice exposed to varying 
doses of whole body irradiation, the effect of total body irradiation 
of antigen-antibody systems in white mice, study of relation of exist 
dose of x-ray generated at various voltages and the lethal effect, 
correlation of lethal effects with organ pathology and with toxic 
products other than histamine, physico-chemical methods of gamma ray 
dosimetry, measurement of adrenal function in total body irradiation, 
histopathology of oral tissues, influence of ionizing radiations on 
dental caries and jaw necrosis, study of the physiological effects of 
germanium, secondary electron studies, and the effect of x-irradiation 
on intestinal motility of the rat.  $148,500

.05  Radiation Treatment. Four phases are being investigated (1) The 
ovulation of sulfhydryl containing agents upon the cause of radiation 
illness. (2) Correlation of predisposition to radiation illness to 
other clinical findings in patients receiving radiation therapy. (3) 
Therapeutic effect of combinations of adrenal cortical hormones, other 
hormones, nucleic acids, vitamins and antihistamines, (4) Basic and 
applied research on formed elements of the blood and plasma fractions.  
$66,000

06. Tissue Dose Measurement of Ionizing Radiation from Atomic Weapons.  
This project develops instrumentation for tissue dositry, ovulates 
tissue doses from atomic weapons, establishes methods to permit 
accurate reproduction in the laboratory of the radiological effects of 
atomic weapons.  $16,500

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NM 006-015     Research in the Application of Medical Principles of 
Atomic Warfare.  Naval Radiological Defense Laboratory.  This project 
has the following subtasks:

.02  Thermal Studies.  Physiological and chemical means are utilized 
in the study of local changes induced in skin and other tissues by 
thermal radiation.

1.   Thermal Effects of Skin            $11,000 AFSWP
2.   Effects of Thermal Burns in Normal and irradiated animals -- 
$138,800 AFSWP

04.  Biological Effects of Radiation

1. Effects of Partial Body Irradiation       $55,000
2. Bacteriological and Immunological Aspects of Irradiation Injury  
50,200
3. Study of Hemorrhagic Effects of Irradiation by Blood Resistance 
Techniques  $28,800
4. Biochemical studies on Biological Systems Exposed to Ionizing 
Radiation. $102,000
5. The Effects of Ionizing Radiation of Lipid Metabolism. $32,000
6. Uptake of Radioactive Iron by Rod Cells as an Index of Altered Bone 
Marrow Function  $12,600.
7. Effects of Exposure to Ionizing Radiation upon Physical Performance 
Ability  $88,300 USAF
8. Effects of Ionizing Radiation of Psychological Performance of 
Irradiated Animals.  $63,000 USAF
9. Effects of Environmental Stresses on Resistance to Radiation Injury 
(This includes work on physiological changes in the irradiated animal 
exposed to stress.) $41,200 USAF
10. In Vivo Studies of X-irradiated Endocrine Tissues  $17,500
11. Biological and Chemical Factors Influencing Radiation Injury  
$73,600
12. The Effects of Neutron Radiation of Physiological Systems. $33,500
13. Studies in Bone Metabolism relative to the Problem of Bone 
Decontamination  $61,200
14. Radiation Effects on Isolated Organs  $71,100
15. Analysis of Physiological Changes in the Irradiated Animal During 
and After Recovery  $44,000
 
05.  Radiation Treatment.  The objective is to endeavor to use 
morbidity as well as mortality critical in the evaluation of suggested 
protective agents.

06. Medical Participation in Atomic Bomb Tests.  Inactive.

TOTAL $928,000*
*Including R&D, Overhead and Travel





14





NR 114-000
020  Endocrine Factors in Burned and Surgical Patients.  H.B. 
Zimmerman, University of Minnesota.  Studies are designed to give 
information on the nature of the adrenal's response to changes in 
blood electrolytes of animals subjected to trauma.  Balance studies 
are also being performed on clinical patients undergoing standardized 
surgical procedures.  $11,680

049 Study on the Effect of Wound Healing in Thermal Injury to the 
Skin. J.A. Schilling, University of Rochester.  A standard wound has 
been developed.  Effects of thermal injury and various organic 
compounds on wound healing are being studied with a view to finding 
agents to accelerate wound healing. $27,000

057 A study of Disturbances in Circulatory Dynamics Following Physical 
Trauma.  T.S. Eliot, University of Colorado.  Crashing or burning 
injuries are known to cause clumping and sludging of blood. This 
circulatory disturbance will be studied and a search made for an 
effective chemotherapy.  $6,250

065 The Pathological Physiology and Experimental Therapy of Burned 
Animals and Men. M.H. Knisely, Medical College, state of South 
Carolina.  Study will determine some of he pathologic circulatory 
factors causing shock and death following burns.  This will utilize in 
vivo microscopic study of the vascular response of peripheral, 
pulmonary, cerebral, hepatic vessels and the sludging of blood within 
the vascular tree.  $29,996 (part AFSWP)

079 Studies on the Mechanism of Traumatic Shock.  D.H. Moore, Columbia 
University. College of Physicians and Surgeons.  Objective of this 
study is to determine the effect of temperature on the survival of 
animals in the state of shock. Analysis of various substances in the 
traumatized region, in blood and in organs is being made in an effort 
to explain the pathophysiology of shock.  $12,600

083 Study of Peripheral Sensory Nerves in Thermal Burns. J.R. Hinshaw, 
University of Rochester.  This is a study of the histology of sensory 
nerve endings before and after thermal burns to determine whether 
changes in the nerve endings themselves or in adjacent tissues are 
responsible for the effects of pain and irritation experienced in 
burns. $8,000

15





NR 114-000 (Continued)

094 Study of Curtain Physiological Changes Produced by Flash Burns. 
J.S. Roth, Hahnemann Medical College and Hospital. This project is 
studying changes in enzyme systems within cells before and after flash 
burns.  Nucleic acid metabolism in burned areas will be studied by 
turnover and uptake of nitrogen labeled purines. $24,320 (AFSWP)

097 Physiological Disturbances Attending Bodily Injury. E.I. Evans, 
Medical College of Virginia. Emphasis at present is centered around 
the manner in which the kidney controls water and in excretion.  
$7,000

111 The Nature of Burn Shock and Thermal Injury.  S.F. Cook and N. 
Pace, University of California. The object is to examine the problems 
of burn shock in terms of the physiological aberrations involved so 
that a better understanding may be obtained of the mechanisms. $48,000

114 Thermal Burn Project.  J.L. Lilienthal, Johns Hopkins University. 
$31,190

140 The Cytological Basis for Functional Changes in the Pituitary 
gland Following Severe Burns. J.C. Finerty, University of Texas  
$6,580

161 Problem of Thermal Injury. S.A. Rosenthal, University of Illinois 
School of Medicine.  Project will study, by direct methods, tho 
substances liberated or produced following burning by thermal means, 
search for chemical or biological means of neutralizing these 
substances, and study the metabolism of normal and burned skin.  
$21,449


185  Local Injury Resulting from Thermal Burning and the Problem of 
Toxic Substances from Thermally Denatured Skin and Subcutaneous Fat, 
R. Ford, Harvard Medical School.  The investigation will determine the 
depth of irreversible thermal injury of tissue, the progression of 
injury due to damage to the vascular bed, and study the relation, if 
any, between the "toxic" effects of extensive third degree burns and 
the violent biologic response observed when burned dermal collagen is 
implanted in the body.
16







113/1
NR 114-000 (Continued)

198  Study of Burns.  O. Cope, Harvard Medical School.  The burn wound 
is being studied in regard to immediate treatment, debridement, and 
healing.  Distribution of electrolytes, fluid balance, and the 
immunity of infection will be studied. $47,000 (Part AFSWP)

209  Bacteriological Aspects of Investigation of Burns.  P.B. Price, 
Salt Lake General Hospital, Salt Lake City, Utah.  this study will 
make quantitative and qualitative measurements of the bacterial flora 
on normal and injured body surfaces and evaluate the effects of wet, 
dry and pressure dressings on this flora. $15,000 (AFSWP)

238 Histochemical Study of Effects of Heat on Skin. A.R. Moritz, 
Western Reserve University School of Medicine. Plan is to characterize 
the extracurricular protein of rat skin, heated under controlled 
conditions, with that of normal rat skin. $2,411

257  Studies of Effects of Thermal Radiation on Human Skin. J.D. 
Hardy, Cornell University Medical School.  Reflectance, transmittancy 
and degree of scattering of skin for visible and infra red radiations 
to 22 microns will be investigated. $22,150 (AFSWP)

258 Studies of Thermal Radiation and Thermal Stress as Applied to 
Human and Animal Physiology.  J.D. Hady, Cornell Medical School.  
Plans to (1) construct a radiometric skin thermometer for recording 
temperature under clothing, (2) study thermal changes in skin which 
evoke sensation and the relation to tissue damage, (3) study the 
response of monkeys and men to hot and cold environments using rapidly 
recording calorimeter and a thermal model of the human temperature 
regulating mechanisms. $30,000

NR 117-196     Plasma Proteins with Labeled Amino Acids. G.H. Whipple, 
University of Rochester. Work is divided between the chemistry, 
radiation biology and pathology departments.  Chemistry department is 
synthesizing labeled amino acids which are fed to donor dogs to obtain 
labeled plasma proteins.  The fate of parenteral plasma proteins and 
their relationship to protein metabolism in general are being studied 
with the above techniques.  $30,000
17






BAW 113/1
NR 117-196 (Continued)

203  Basic Studies in Endocrinologic Aspects of the Radiation 
Syndrome. D.J. Kimeldorf, USNRDL. Project will determine the 
alterations in hormone production and tissue sensitivity to hormones 
which may occur during radiation sickness.  This sensitivity will be 
determined by means of intra-ocular implant techniques. $8,000

581 Biological Effects of High Voltage Radiation. L.B. Clark,Union 
College, Schenectady, N.Y.  The effect of high x-ray radiations f 
order of 100 million volts o enzyme systems of cells is being studied. 
$15,000

NR 182-000     ORAL EFFECTS OF IONIZING RADIATION
002  Influence of Ionizing Radiations on Salivary Bacteriologic 
Defense. J.L. Hemes, University of Maryland.  Purpose is to study the 
define mechanisms of oral cavity, the activity of lysozyme-like 
components of saliva,and effect of radiation on salivary defense to 
bacterial invasion.  $4,250.

007  Histopathology of Radiated Oral Tissue and Technician Training.  
P.E. Boyle, University of Pennsylvania.  The problem is to study the 
histology and pathology of a large stock of tissue specimens from 
naval experimental animals previously subjected to ionizing 
radiations. In addition a training program to equip technicians with 
skills in hard tissue preparations has been set up.  $8,500.

008  Oral and Alimentary Effects of Ingestion of Radioactive Elements. 
H. Becks, University of california.  This study is concerned with the 
effect or oral administration of the radioactive elements, stimulating 
contaminated food and water supply, on the mouth, GI tract, and other 
organs of the rat, using Ca 45, Sr 89, P 32.  Rapid fixation and 
embedding techniques for tissues are being developed for the use of 
short lived isotopes.  $13,020

704  Metabolism of Radioactive Phosphorus and Strontium in Dental and 
Skeletal Structures. H. Becks, University of California.  Rats have 
been made phosphorus deficient and the uptake of P 32 is being studied 
in different teeth and tissues.

18





113/1
21-3501-000    MEDICAL PROBLEMS PECULIAR TO ATOMIC WARFARE - AIR 
FORCE*

001  Effect of Irradiation of P 32 Uptake by Bone Marrow.  Bone Marrow 
P-32 uptake is impaired after irradiation.  A quantitative method for 
uptake has been developed.  The effect of drugs, hormonal factors, 
nutritional constituents and environmental conditions (anoxia) on the 
P 32 uptake will be studied. Dosoxyribonacleic acid analysis of marrow 
and spleen are being studied as other indicators of marrow injury.  
$46,000

0002      Antibody Response of Animals Exposed to X-radiation.  USAF 
School of Aviation Medicine. Project is reported to be terminated in 
1952.  Studies have been done to determine the effects of additional 
antigen and adrenal cortical extract on antibody titers or rabbits 
immunized with S. typhosa and later treated with x-radiation.  Tests 
of protection by glutathione and chloromycetin on survival of 
irradiated, immunized and infected mice have been designated.  
Undetermined.

0003      Effects of Ionizing Radiation Upon Physical and 
Psychological Functions in Various Species. (1) Rodent phase  USAF 
School of Aviation Medicine. Studies on learning, retention, visual 
acuity, brightness discrimination have been competed. (2) Primate 
phase  C.W. Dallanbach, University of Texas. Serial learning, 
retention, discrimination and other psychological functions are being 
tested in a colony of 20 Rhesus monkeys and 2 chimpanzees. (3) Human 
phase  R.T. Clark, University of Texas. Psychomotor tests have been 
administered to patients undergoing various amounts of radiation 
therapy.  Undetermined.  $275,000 Includes building funds) $32,000

0004      Hypersensitivity phenomena and Change sin Blood Protease, 
Protease Inhibitor Titers After Exposure to External X-radiation.  
K.L. Burdon, College of Medicine, Baylor University.  This project 
will study the changes which occur in the titers of blood protease and 
protease inhibitor following irradiation of guinea pigs, mice, and 
rabbits; and patients after known doses of x-radiation for therapy. No 
reports.  $17,000

*This list does not include research on burns done at School of 
Aviation Medicine and Wright Air Development Center

19






BAW 113/1

21-3501-0000 (continued)

0005      Biological and Medical Aspects of Ionizing Radiation.  Work 
takes place as USAF School of Aviation Medicine and University of 
Chicago, USAF Radiation Laboratory.  A wide number of projects are 
reported underway at these laboratories.  (1) At School of Aviation 
Medicine work is being done on effects of ionizing radiation on 
biochemistry of cells, the treatment of whole body radiation, sickness 
in dogs with replacement transfusions, effects of anesthesia radiation 
injuries, analysis of ionizing radiation hazards to air crews, etc.  
University of Chicago current projects under investigation include 
attempts at concentration of mucoprotein from rat intestine, 
x-radiation inhibition of tissue carboxypopidase, effects of roentegen 
rays on mammalian heart, effects on enzymes ,etc.
Undetermined.   At $250,000

AFSWP 1-08-51  Investigation of Local Lesions and Flash Burns.  
project and funds are reported under NR 114-000, NM 006-015, 
6-59-12-021.

1-09-51   Therapy of Radiation Syndrome.  Project and funds are 
reported under 6-59-08-013, NM 006-01, except for the following:
(1) Therapy of Acute Radiation, J. Howland, University of Rochester.  
$65,000
(2) Effectiveness of Various Antibiotics as Agents.  W. W. Smith, 
national Institutes of Health.  $32,776

1-10-51   Investigation of the Effect of Ionizing Radiation on Humans






BAW 113/1  SECURITY INFORMATION CONFIDENTIAL
SUPPLEMENT I
PROJECTS IN SUBJECT FIELDS OF AW-6 BUT WHICH 
ARE LISTED UNDER OTHER TECHNICAL OBJECTS

RADIATIONNM 001-059.13Some Conclusions and Calculations from the 
Present Day Knowledge of Cosmic Radiation with Regard to the Actual 
Radiation Exposure in High Altitude Flight.  H. Shaeffer, School of 
Aviation Medicine, Pensacola, Florida.

NM 001-059.18  Measurement of Radiation and Emanation Doses from 
Luminous Pain on Instrument Dials in Airplanes.  School of Aviation 
Medicine, Pensacola, Florida.

NM 001-059-23  Micropathological Studies of the Effects of Radiation 
from Internal Sources on Living Cells.  School of Aviation Medicine, 
Pensacola, Florida.

NM 001-059.25  The Effects of Exposure of Living Animals to Cosmic 
Radiation at Extremely High Altitudes.  School of Aviation Medicine, 
Pensacola, Florida.

NM 001-080     Early Effects of Small Amounts of Alpha Radiation (from 
Therotrast) Upon Mammalian Cells.  W.H. Sheldon, Emory University, 
Medical School

NM 007.090-12  Effect of Radiation on Antibody Production in the Human 
Receiving Therapeutic Abdominal X-Ray. U.S. Naval Hospital, Oakland, 
California.

NM 007-090.14  Effect of Radiation on Antibody Production in the 
Human, Receiving Therapeutic Abdominal X-Ray. U.S. Naval Hospital, 
Oakland, California.

NM 007-018.12  Effects of Autogenous Blood and Plasma Transfusions 
Upon the Peripheral Blood Cell Population and the Hematopoietic 
Tissues of Rabbits Exposed to Total Body Irradiation.  Naval Medical 
Research Institute, Bethesda, Maryland.

BURNS AND PLASMA VOLUME EXPANDERS

NM 007-081.03  Investigation of Protective and Therapeutic Measures 
for Burns Occurring in the Naval Service. NMRI, Bethesda, Maryland

THIS DOCUMENT CONTAINS INFORMATION AFFECTING THE NATIONAL DEFENSE OF 
THE UNITED STATES WITHIN THE MEANING OF THE ESPIONAGE LAWS, TITLE 18, 
U.S.C., SECTIONS 793 AND 794.  ITS TRANSMISSION OR THE REVELATION OF 
ITS CONTENTS IN ANY MANNER TO ANY UNAUTHORIZED PERSON IS PROHIBITED BY 
LAW.






SECURITY INFORMATION CONFIDENTIAL

BAW 113/1

NM 007-088.06  Treatment of Burned Cases with ACTH and/or Cortisone.  
U.S. Naval Hospital, San Diego, California

NM 007-090.05  Clinical Investigation to Devise Improved Parenteral 
Fluids to be Used as Blood Substitutes.  U.S. Naval Hospital, Oakland, 
California.

NM 007-090.06  Clinical Investigation of the Polylsaccharrides, 
Including Their Characteristics for Use as Plasma Substitute in Acute 
Blood Loss.  U.S. Naval Hospital, Oakland, California.

NM 007-090.15  Clinical Investigation of Oxypolygelatin as a Plasma 
Volume Expander.  U.S. Naval Hospital, Oakland, California

NM 007-093.01  Clinical Study of Dextran as a Plasma Substitute. U.S. 
Naval Hospital, Yokosuka, Japan.

NR 102-000.005      Use of Dextran for Treatment of Shock. J.D. Myers, 
Duke University Medical School

NR 102-000.043      Effects of Dextran in Increasing Osmotic Pressure 
of Plasma. J. Humpry-Long, University of Pennsylvania School of 
Medicine.

NR 102-000.060      Physiological Properties of Plasma Substitutes.  
J.L. Crimson, Stanford University School of Medicine.

21-53-007      Studies on Blood Plasma Substitutes.

21-1207-0005   Therapy of Ocular Burns.







BAW 113/1  SECURITY INFORMATION CONFIDENTIAL
SUPPLEMENT III
PUBLIC HEALTH SERVICE RESEARCH PROGRAM
IN THE SUBJECT FIELDS OF AW-6*

BURNS                                             $299,521

1.   Studies in Experimental Therapeutics and Pharmacology. S. M. 
Rosenthal, NIH.  This includes studies in the mechanism and therapy of 
experimental shock, including burn shock. $150,000

2.   Chemical Methods for the Removal of Devitalized Tissue from 
Burned Areas. V. E. Siler, University of Cincinnati School of 
Medicine. $9,774

3.   Study of Effect of Adrenocorticotropic Hormone on the Course of 
Thermal Burns. J.D. Martin, Emery University School of Medicine. 
$8,100

4.   Study of Effects of Trauma, including Burns. W.D. Abbott, Western 
Reserve University School of Medicine. $11,702

5.   Studies of Proteinmetabolism in Burn Patients by Radioisotope 
Techniques. T.G. Blocker, University of Texas School of Medicine. 
$20,000

6.   Experimental Histochemical Study of the Effects of Host on 
Certain Extracellular Protein Complexes of the Skin. A.R. Moritz, 
Western Reserve University School of Medicine.  $5,292

7.   Changes in Intracellular Electrolytes in Surgical Patients, 
Including Burned Patients. J.W. Raker, Harvard Medical School. $8,418

8.   Study of the Use of Sodium Salt Solutions in the Treatment of 
Burn Shock to Replace Stockpiling of Plasma, J.M. Winfield, N.Y. 
Medical College, Flower and Fifty Avenue.  $31,752

9.   Evaluation of therapy in Surgical Shock with Radioactive Sodium, 
Including a Study of Shocked Dogs Undergoing Therapy with Saline 
Alone. A.F. Burton, Howard University College of Medicine.  $10,000



THIS DOCUMENT CONTAINS INFORMATION AFFECTING THE NATIONAL DEFENSE OF 
THE UNITED STATES WITHIN THE MEANING OF THE ESPIONAGE LAWS, TITLE 18, 
U.S.C., SECTIONS 793 AND 794.  ITS TRANSMISSION OR THE REVELATION OF 
ITS CONTENTS IN ANY MANNER TO ANY UNAUTHORIZED PERSON IS PROHIBITED BY 
LAW.






BAW 113/1
SECURITY INFORMATION CONFIDENTIAL

SUPPLEMENT II
ATOMIC ENERGY COMMISSION RESEARCH PROGRAMS IN THE 
SUBJECT FIELDS OF AW-6, EXCLUSIVE OF THE MAJOR
SECTIONS OF THE BIOMEDICAL PROGRAM, RADIATION STUDIES:

BURNS                                             $165,000
1.   Physiological and Pathological Aspects of Thermal and Flash 
Burns.  A.R. Moritz, Western Reserve University Medical School.  
$30,000.  This is a biochemical study of burned tissue.

2.   Studies on Flash Burns.  H. Pearse, University of Rochester 
School of Medicine.  $100,000

3.   Immunological Aspects of Skin Transplantation.  F.W. Co Tui, 
Creedmore State Hospital, N.Y., and J.M. Converse, New York 
University, $35,000

RADIATION
Summary not attempted.  See Eleventh Semiannual Report AEC for 
unclassified contract research.

BLAST                                             $125,000
1.   Indirect Blast Injuries. W. R. Lovelace, J. Grossman, J. Hickman, 
C.S. White, R. Kniseley, and H. Halpern.  Lovelace Foundation for 
Medical Education and Research, Albuquerque, New Mexico.  Joint AEC 
and USAF support, $100,000.  This includes studies of (1) body 
displacement from overpressures, and (2) movement of missiles, 
contaminated and uncontaminated.

2.   Blast Studies.  S. Warren, UCLA Medical School. $25,000.  A stock 
tube is available for experimental studies on mice.




THIS DOCUMENT CONTAINS INFORMATION AFFECTING THE NATIONAL DEFENSE OF 
THE UNITED STATES WITHIN THE MEANING OF THE ESPIONAGE LAWS, TITLE 18, 
U.S.C., SECTIONS 793 AND 794.  ITS TRANSMISSION OR THE REVELATION OF 
ITS CONTENTS IN ANY MANNER TO ANY UNAUTHORIZED PERSON IS PROHIBITED BY 
LAW.








BAW 113/1
10.  Evaluation of Saline Therapy in Burns and Shock. A Hurtado, 
Faculted de Medicine, Lima, Peru.  $16,983

11.  Study of The Preservation of the Blood, Formed Elements f the 
Blood, Blood Derivatives and Saline in Man and Animals.  I.S. Ravdin, 
University of Pennsylvania School of Medicine. This includes the 
evaluation of saline in shock due to burns. $27,500

RADIATION                                    $1,072,8820

A.   Primate Studies

1.   Minimal Radiation and Primate Behavior, T.C. Ruch, University of 
Washington.  $21,176

2.   Effects of Ionizing Radiation on Subhuman Primates with 
Particular Attention to the Gastrointestinal Tract and the CNS. J.Z. 
Bowers, University of Utah School of Medicine. $24,732.

3.   Physiological Effects of X-Radiation in Dogs and Monkeys.  M.L. 
Grerersen, Columbia University.  $18,576

4.   Effects of Total Body Irradiation on Subhuman Primates. C.A. 
Doan, Ohio State University School of Medicine. $69,362

5.   Performance and Histopathology of Monkeys as a Function of Lethal 
and Sublethal Radiation. R. T. Davis, University of South Dakota 
Medical School.  $7,587

6.   Radiation and Brain (Monkeys). H.W. Magon, University of 
California.  $45,573

7.   Effects of X-ray Treatment on the Ovary of the Monkey. W.U. 
Gardner, Yale University School of Medicine. $9,000

8.   Effect of Ionizing Radiation on the Physiological Activity of the 
Nervous System in Adult and Fetal Mammals. L.B. Aroy, Northwestern 
University Medical School. $23,976

B.   Others

1.   Research in Nuclear Radiation Biology.  H.L. Andres, Laboratory 
of Physical Biology, NIH. Objective of this project is the 
determination of the significant mechanisms involved in the biological 
damage and related effects which result from high energy radiation.  
$250,000
2







BAW 113/1 SECURITY INFORMATION CONFIDENTIAL

2.   Biological Action of Ionizing Radiation. E. Lorenz, Laboratory of 
Biophysics NIH. Studies include biologic effects of radiation in 
laboratory animals, intermediary metabolism of essential amino acids, 
physiological effects including respiratory metabolism, molecular 
changes, pH changes, histopathologic studies, physics, domietry, 
radiobiology of radiation above the Mev energy, etc. $200,000

3.   Interrelationship of the Blood Clotting Mechanism and the Ability 
of the Reticuloendothelial System to Form Antibodies in Radiation 
Injury. H.G. Kupfer, Medical College of Va. $8,138

4.   Search for Substances and Methods to Raise the Resistance to 
Infection in Irradiated Animals. S. Marcus, University of Utah School 
of Medicine. $6,750

5.   Investigation of Factors Responsible for Radiation protection by 
Post-Irradiation Parabiosis. M. Schneider, University of Texas Medical 
Branch. $5,670

6.   Exploration of the Ability of ACTH, Cortisone and Allied 
Substances to Modify Reactions to Ionizing Radiations in Humans. J.J. 
Nickerson, Sloan-Kettering Inst.  $43,150

7.   Study of the Hemolytic Component of Post-Irradiation Anemia. C. 
Wright, Ohio State University School of Medicine. $19,902

8.   Nature of the Changes Induced in Living Cell by Irradiation. B.P. 
Kaufmann, Carnegie Institute.  $8,863

9.   Factors Affecting wound Healing, Including Effects of Irradiation 
on the Tensile Strength of Wounds. H. Bradshaw, Bowman Gray School of 
Medicine. $2,403

10.  Studies on Erythrocyte-antibody Reactions in Animals, Including 
Use of the Investigation of the Hemolytic Effect of Radiation. 
L.Young, University of Rochester. $13,000

11.  Medical Application of the Betatron. H. Quastler, Carle 
Foundation, Urbana, Illinois.  $9,720

12.  Tumorigenesis in Monkeys, Including the Effects of X-Rays Upon 
Ovarian Function in Monkeys Receiving 600r Whole Body Irradiation.  
$13,000

13.  Hair and Skin Cycles as Related to Radiation and Chemical 
Treatment. H.B. Chase, Brown University.  $7,000





BAW 113/1  SECURITY INFORMATION CONFIDENTIAL

14.  Effects of Betatron Electron Beam on Bone and Cartilage. R.A. 
Harvey, University of Illinois College of Medicine. $15,000

15.  Studies on Mechanism of Suppression and Stimulation of Normal 
Hematopoietic Tissue, including Attempts to Reduce the Depressant 
Effect of Radiation on Blood Formation. L.Jacobson, University of 
Chicago.  $21,486

16.  Study of the Osteonecrosis Occurring in Bone After Local High 
Intensity Irradiation. P. DeBruyn, Univ. of Chicago.  $6,976

17.  An Investigation of Physical and Biological Properties and Long 
Term Therapeutic Effectiveness in Cancer of X-rays Generated in the 
Range of 2 Mev. S.T. Cantril, Tumor Inst. f Swedish Hosp. $88,341

18.  Experimental and Clinical Aspects of the Pathogenesis of the 
Acute Radiation Syndrome. S. Warren, NE Deconess Hospital, Boston, 
Massachusetts $11,718

19.  Clinical Investigation of a 22 Mev Betatron in the Treatment of 
Cancer. G. Fletcher, M.D., Anderson Hospital, Houston, Texas. $81,724

20.  Design, Development and Testing of a Medical Linear Electron 
Accelerator for High Energy Radiation Therapy. E.L. Ginzton and H.S. 
Kaplan, Stanford University.  $38,126

21.  Effects of Betatron Radiation on the Eye. W.F. Hughes.  $13,471








BAW 113/1
CONFIDENTIAL SECURITY INFORMATION

SUPPLEMENT IV

RESEARCH BUDGETS IN THE FIELD OF AW-5*

AW-5a     ...equipment and techniques for the detection measurement, 
and evaluation of radioactivity

1951**    1952**    1953**    1954**
3,594     3,572     3,729     3,142

     

AW-5B     ...equipment and technique for the protection of personnel 
and material to minimize the hazards of atomic attack.

1951**    1952**    1953**    1954**
416       573       863       1,523



AW-5c     ...equipment and techniques for decontamination of 
radiologically contaminated personnel and materials.

1951**    1952**    1953**    1954**
474       1,023     980       976

*    Resources Division, RDB

**   In Thousands of Dollars