ATTACHMENT 3







The effect of Total Body Irradiation on Immunologic Tolerance of Bone 
Marrow and Homografts of Other Living Tissue

Location:
     Baylor University College of Medicine
     Texas Medical Center
     Houston, Texas
     approximately 1953 - 1964.

Researchers:
     Vincent P. Collins, M.D., Baylor University, Principal
     Investigator
     R. Kenneth Loeffler, M.D., Baylor University

Organization:
     This research was conducted by the Baylor University College of 
Medicine.  The work was initially supported under Armed Forces Special 
Weapons Project (AFSWP) contract DA-49-007-MD-428 and then supported 
by the Defense Atomic Support Agency (DASA) contract DA-49-146-XZ-032.

Subjects:
     The subjects were patients at the Texas Medical Center.  The 
majority had generalized neoplastic conditions.  There were 112 
patients treated in the study.  Exposures ranged from 25r-250r in 1 
day to 25r-545r over periods of time from 4 days to 3.5 years.

Purpose:
     The goal of treatment by total body irradiations for patients 
disseminated cancer is relief of symptoms.  Despite the fact that many 
patients were approaching the terminal stage when referred for 
treatment, therapeutic response was evident in may by decrease in size 
of nodes, relief of impending obstruction and by decreased narcotic 
requirements subsequent to relief of pain.  In some instances, 
response was dramatic;; a few completely bedridden patients became 
ambulatory and several experienced long term remissions.  Among the 
112 patients there were more than 30 different types of cancer; since 
total body irradiation was given only for generalized disease, a 
survival of one year or even temporary remission was gratifying.  
Extensive data from clinical observations and laboratory tests were 
reported in series of reports to AFSWP and DASA throughout the period 
of the study.

Value to DoD:  In his summary report, Dr. Collins indicated a set of 
tables predicting the effect of total body irradiation based on 
clinical observations.  He also included detailed and extensive tables 
of biochemical effects and hematological data.  All of this can and 
probably was used to support predictive analysis of radiation effects 
on troops in a wartime environment.

Records:
     Currently identified records are the reports submitted to





AFSWP and DASA by the University of Baylor.  The titles and dates





of the reports indicate that certain reports are missing; the  missing 
reports are being sought for review.

Prepared by:   CAPT C.B. GALLEY,AFRRI,  ((310)-295-1048)






POST-IRRADIATION SYNDROME IN MAN

Location:
     Sloan Kettering Institute for Cancer Research (SKICR)
     410 East 68th Street New York 21, New York
     1 July 1954 to 31 January 1961

Researchers:
     James J. Nickson, MD - Sloan Kettering - Principal Investigator
     Henry J. Kock, MD - Sloan Kettering
     Arvin S. Geicksman, MD - Sloan Kettering

Organization:
     This research was conducted by the Sloan Kettering Institute for 
     Cancer Research.  The work was initially supported under U.S. 
     Army contracts DA-49-007-MD-533 and DA-49-007-MD-669 and then 
     supported by the Armed Forces Special Weapons Project (AFSWP) 
     contract DA-49-146-XZ-037.

Subject:
     The subjects were patients at the SKICR all with widespread 
     cancer.  Twenty-two patients received total body irradiation 
     (TBI) and 12 received radiation to the head for treatment of 
     tumors.  The subjects are identified by initials, types of 
     cancer, and, in some cases, by age and sex.  The population was 
     3:1 female to male with ages from 19 to 63 with an average age of 
     47 years.

Purpose:
     Available reports have been reviewed.  The patient selection 
     required that patients with radiation sensitive lesions be 
     excluded.  The aim of the study was to evaluate the efficacy of 
     radiation in the treatment of widely spread cancers that were 
     intractable to treatment.  The investigators did observe whole 
     body effects on the patients but that was secondary to the 
     evaluation of radiation as a treatment modality.  Since the 
     primary intent of the study was to treat cancer and provide a 
     direct benefit to the subjects, apparently the Nuremberg Code and 
     the Declaration of Helsinki were complied with.  The radiation 
     source was commonly a Van de Graaf generator.  Doses ranged from 
     50 to 150R for the TBI and up to 4000R was used for irradiation 
     of localized cancers.  In addition to the cancer treatment 
     information, data was collected on: clinical observations, 
     hematologic parameters, plasma protein distribution, urine 
     excretion, and electroencephalograms.  These observations were 
     reported to the AFSWP.  There is no record of clinical follow-up 
     beyond the 75 day post exposure period (the greatest reported 
     period).

Records:
     Currently identified records are the reports submitted to the 
     AFSWP by the SKICR.  The titles and dates on the reports





     indicate that certain reports are missing; the missing reports 
     are being sought for review.

Prepared by:  CAPT C. B. GALLEY, AFRRI, ((310)-295-1048)