Attachment 1

               LOS ALAMOS  NATIONAL LABORATORY

OVERVIEW

Type of institution: National Laboratory

Mission: Weapons development;  Occupational health and safety of 
laboratory and other nuclear workers;  Bomb related biomedical 
research  

Links: University of California, Dept. of Defense (at least SAM and 
NRDL); Los Alamos Medical Center, Oak Ridge, VA

Experiments or other radiation research:   
*    Ways to estimate body content from measurement of  
     excretion(bioassay)
*    Molecular and cellular radiation biology
*    Mammalian radiobiology using external radiation sources 
*    Isotope application section  
*    Environmental studies
*    Thyroid function measurements using radioiodine
*    Calibration and cross-calibration of a human counter ("HUMCO II")
*    Tracer studies with various radionuclides
*    Gastrointestinal transmit time of microspheres
*    Absorption, distribution, and excretion of tritium
*    Retention and excretion of selected radionuclides
*    Skin absorption of selected radionuclides
*    Pion therapies
*    Intentional releases: Open air, high explosive testing involving 
     radiolanthanum
*    Total body irradiation
*    Human fly-throughs of atomic clouds and other bomb test related 
     experiments
*    Tissue studies 
*    Chelation 
*    Cholesterol studies
*    Fallout related studies (e.g. Operation Sunshine)

Secret or classified research: Yes, but nature, extent, and role not 
yet explored 



AVAILABLE DATA 

Experiments: 
*    Histories of research program: Bomb Test History
*    "Start/stop" documents for specific experiments/programs:  
     Correspondence related to various experiments. Protocols not yet 
     made available
*    Publications or reports for specific experiments/programs : 
     Health Division annual and bi-monthly reports which discuss 
     ongoing research, research plans and progress and list
     publications related to research. 

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Program:
*    Record of chains of command for program decisions and review : 
     Chain of command documents on the bomb tests ;  Organizational 
     charts for Los Alamos and H division; Periodic reports of H 
     division
*    Funding source:  Some funding discussions in the Shields Warren 
     diaries

Was there secret or classified funding? Yes, but this issue has not 
yet been explored

Consent:  What was the extant consent policy? 
*    In a 1951 letter to a Los Alamos official, which purported to 
     respond to Los Alamos' inquiry, the AEC indicated that written 
     informed consent should accompany human experimentation.
*    July 5, 1956 letter from the Director of the Atomic Energy 
     Commission Division of Biology and Medicine to the Health 
     Division Leader at Los Alamos stated that subjects in tracer 
     experiments should be "bona fide volunteers and fully informed as 
     to the procedure involved. . . ."
*    The  institutional form for the policy:  Unknown
*    Records of implementation: Not yet identified

Subject selection: 
     Subjects included laboratory workers and their families, 
townspeople, and patients recruited from the region. There is 
correspondence on recruiting and transporting subjects.  The extent to 
which all groups of subjects received the benefits of any ethics 
policies remains to be discovered.

OVERSIGHT

          Unknown at this time.

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