Attachment 1 TBI Research - 1930-74 I. TBI for Radiosensitive Disorders 1. Ellis Fischel Cancer Hospital, Columbia, Missouri and Penrose and Cancer Hospital, Colorado Springs (Chronic Lymphogenous Leukemia) Juan A. Del Regato, "Total Body Irradiation in the Treatment of Chronic Lymphogenous Leukemia," American Journal of Roentgenology, Vol. 120, at 504-520 (1974). 2. Mary Imogene Bassett Hospital, Cooperstown (Acute Leukemia/Bone Marrow Transplants) E.D. Thomas, H.L. Lochte, & J.W. Ferrebee, "Irradiation of the Entire Body and Marrow Transplantation: Some Observations and Comments," in The Journal of Hematology, Vol. 14, at 1-23 (1959). E.D. Thomas, H.L. Lochte, Wan Ching Lu, & J.W. Ferrebee, "Intravenous Infusion of Bone Marrow in Patients Receiving Radiation and Chemotherapy," New England Journal of Medicine, Vol. 257, at 491-96 (1957). 3. Massachusetts General Hospital (Leukemia) J.J. McGovern, P.S. Russell, L. Atkins, & E.W. Webster, "Treatment of Terminal Leukemic Relapse By Total-Body Irradiation and Intravenous Infusion of Stored Autologous Bone Marrow Obtained During Remission," New England Journal of Medicine, Vol. 260, at 675-683 (1959). 4. Montefiore Hospital, New York (Lymphoma) J. Greenberg & D. Laszlo, "The Influence of Ionizing Radiation on the Body Fluid Compartments of Patients with Malignant Lymphoma," Journal of Clinical Investigation, Vol. 34, at 405-416 (1955) 5. National Cancer Institute (Chronic Lymphocytic Leukemia) Ralph E. Johnson, "Total Body Irradiation with Fractioned Dosage Schedules. Frontiers in Radiation Therapy and Oncology," San Francisco Cancer Symposium. Vol. 3, at 152-162 (1967). Ralph E. Johnson, "Total Body Irradiation of Chrome Lymphocytic Leukemia: Incidence and Duration of Remission, "Cancer, Vol. 25, at 523-530 (1970). 6. Oak Ridge Institute of Nuclear Studies/Oak Ridge Associated Universities (Lymphoma, Leukemia, Polycythemia Vera) G.A. Andrews, F.V. Comas, C.L. Edwards, R.M. Knisely, & C.C. Lushbaugh, "Hematologic and therapeutic effects of total-body irradiation (50R-100R) in patients with Malignant Lymphoma, Chronic Lymphocytic and Granulocytic Leukemias, and Polycythemia Vera," USAEC, ORAU-112 (Dec. 1972). 7. Presbyterian-St. Luke's Hospital, Chicago (Ewing's Sarcoma) L.F. Millburn, L. O'Grady, & F.R. Hendrickson, "Radical Radiation Therapy and Total Body Irradiation in the Treatment of Ewing's Sarcoma," Cancer, Vol. 22, at 919-925 (1968). 8. Princess Margaret Hospital, Toronto, Canada (Ewing's Sarcoma) R.T.D. Jenkin, W.D. Rider & M.J. Sonley, "Ewing's Sarcoma: A Trial of Adjuvant Total-Body Irradiation," Radiology, Vol. 96, at 151-155 (1970). 9. University of Oregon Medical School (Leukemia) Edwin E. Osgood, A.J. Seaman & H. Tivey, "Comparative Survival Times of X-Ray Treated Versus P-32 Treated Patients with Chronic Leukemias Under the Program of Titrated, Regularly Spaced Total-Body Irradiation," Radiology, Vol. 64, at 373-381 (1955). 10. University of Washington School of Medicine, Seattle (Leukemia/Bone Marrow Transplantation) C.D. Buckner, R.B. Epstein, R.H. Rudolph, A.R. Clift, R. Storb, & E.D. Thomas, "Allogenic Marrow Engraftment Following Whole Body Irradiation in a Patient with Leukemia," in The Journal of Hematology, Vol. 35, at 741-749 (1970). 11. [Institution Unknown] (Ewing's Sarcoma) W.D. Rider, & R. Hasselback, "The Symptomatic and Hematological Disturbance Following Total Body Radiation of 300-Rad Gamma-Ray Irradiation," International Conference on Guidelines to Radiological Health, at 139- 144 (1967). 2 II. TBI for Radioresistant Disorders 12. Memorial Hospital, 1931-40 Fred G. Medinger & Lloyd F. Craver, "Total Body Irradiation, with review of cases," Am. J. Roent, Vol. 48, at 651-671 (1940). L.F. Craver, "Tolerance to Whole-Body Irradiation of Patients with Advanced Cancer," in Robert S. Stone, ed., Industrial Medicine on the Plutonium Project: Survey and Collected Papers 338 (1951) (National Nuclear Energy Series (NNES), Div. IV, Vol. 20) hereafter Industrial Medicine), at 486. 13. University of California Hospital (San Francisco) Low-Beer & Robert S. Stone, in Industrial Medicine on the Plutonium Project at 338-418. 14. Chicago Tumor Clinic J.J. Nickson, "Blood Changes in Human Beings Following Total-Body Irradiation," in Industrial Medicine, at 308-37. 15. M.D. Anderson Hospital, 1951-56 Lowell S. Miller, Gilbert H. Fletcher, and Herbert B. Gerstner, "Systemic and Clinical Effects Induced in 263 Cancer Patients by Whole Body X-Irradiation with Nominal Air Doses of 15 to 200 R," No. 57-92, USAF, SAM (May 1957) ["SAM Report"]; "Radiobiologic Observations on Cancer Patients Treated with Whole-Body X-Irradiation," Radiation Research, Vol. 4, at 150-65 (1958). 16. Vincent P. Collins and R. Kenneth Loeffler, "The Therapeutic Use of Single Doses of Total Body Radiation," Am. J. Roent., Vol. 75, at 546 (1956). "Study of the Effects of Total and Partial Body Radiation on Iron Metabolism and Hematopoiesis"; by the end it was to study "The Effect of Total Body Irradiation on Immunologic Tolerance of Bone Marrow and Homografts of Other Living Tissue." Armed Forces Special Weapons Project (AFSWP) contract no. DA-49-007-MD-428; DASA contract DA-49-146-XZ-032. 3 17. Sloan-Kettering Institute for Cancer Research (Memorial Hospital) U.S. Army Contracts DA-49-007-MD-533 and DA-49-007-MD- 669; AFSWP contract no. DA-49-146-XZ-037. 18. Naval Medical Research Institute, 1959-60 Capt. E. Richard King, "Use of Total-Body Radiation in the Treatment of Far Advanced Malignancies," J.A.M.A., Vol. 177, at 86-89 (Sept. 2, 1961). Ralph R. Cavalieri, Milton Van Metre, F.W. Chambers, & R. Richard King, "Taurine Excretion in Humans Treated by Total-Body Radiation," J. Nuc. Med. Vol. 1, at 186 (1960). 19. City of Hope Medical Center Melville, L. Jacobs & Fred J. Marasso, "A Four- Year Experience with Total-Body Irradiation," Radiology, Vol. 84, at 452-52 (Mar. 1965). 20. University of Cincinnati Eugene L. Saenger, Edward B. Silberstein, Bernard Aron, Harry Howitz, James G. Kereiakes, Gustave K. Bahr, Harold Perry, and Ben I. Friedman, "Whole Body and Partial Body Radiotherapy of Advanced Cancer," Am. J. of Roent., at 670 (Mar. 1973) "Metabolic Changes in Humans Following Total Body Irradiation," DASA contract no. DA-49-146-XZ-029.